Human Reproduction, Vol. 14, No. 3, 698-703,
March 1999
© 1999 European Society of Human Reproduction and Embryology
Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome
1 The Family Federation of Finland (The Oulu Infertility Clinic), Kiviharjuntie 11, FIN-90220 Oulu, 2 Department of Obstetrics and Gynecology, Oulu University Hospital, Kajaanintie 50, FIN-90220 Oulu, and 3 Medical Informatics, Faculty of Medicine, University of Oulu, Kajaanintie 52, FIN-90220 Oulu, Finland
A total of 811 intrauterine insemination (IUI) cycles in which clomiphene citrate/human menopausal gonadotrophin (HMG) was used for ovarian stimulation were analysed retrospectively to identify prognostic factors regarding treatment outcome. The overall pregnancy rate was 12.6% per cycle, the multiple pregnancy rate 13.7%, and the miscarriage rate 23.5%. Logistic regression analysis revealed five predictive variables as regards pregnancy: number of the treatment cycle (P = 0.009), duration of infertility (P = 0.017), age (P = 0.028), number of follicles (P = 0.031) and infertility aetiology (P = 0.045). The odds ratios for age <40 years, unexplained infertility aetiology (versus endometriosis) and duration of infertility 
6 years were 3.24, 2.79 and 2.33, respectively. A multifollicular ovarian response to clomiphene citrate/HMG resulted in better treatment success than a monofollicular response, and 97% of the pregnancies were obtained in the first four treatment cycles. The results indicate that clomiphene citrate/HMG/IUI is a useful and cost-effective treatment option in women <40 years of age with infertility duration 6 years, who do not suffer from endometriosis.
Key words: clomiphene citrate/human menopausal gonadotrophin/infertility/intrauterine insemination/prognostic factors
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