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Human Reproduction, Vol. 14, No. 4, 893-897, April 1999
© 1999 European Society of Human Reproduction and Embryology

Effect of ovarian suppression on glucose metabolism of young lean women with and without ovarian hyperandrogenism

A. Cagnacci1,3, A.M. Paoletti2, S. Arangino1, G.B. Melis2 and A. Volpe1

1 Institute of Obstetrics and Gynaecology of Modena, via del Pozzo 71, 41100 Modena and 2 Institute of Obstetrics and Gynaecology of Cagliari, via Ospedale 46, 09124 Cagliari, Italy

Gonadal steroids are believed to influence glucose metabolism, oestrogens inducing an improvement and androgens or progestins a deterioration. At baseline and after 3 months of ovarian suppression with a gonadotrophin-releasing hormone analogue (GnRHa: goserelin depot 3.75 mg/28 days), glucose metabolism was evaluated in eight lean women affected by ovarian hyperandrogenism (PCOS) and six age–weight-matched non-hyperandrogenic women (controls) by using both an oral glucose tolerance test (75 g; OGTT) and the minimal model method. The latter method allows calculation of peripheral insulin sensitivity (Si) and glucose dependent glucose utilization (Sg). In PCOS, higher fasting concentrations (P < 0.05) of insulin and C-peptide, and lower Sg (P < 0.05) and Si (P < 0.01) were found. GnRHa did not significantly modify glucose metabolism of controls, while in women with PCOS it decreased fasting glucose (P < 0.05) and significantly increased Si (P < 0.03) up to control values. The present data indicate that strong suppression of ovarian activity improves Si in lean women with PCOS, while it is without relevant effects on glucose metabolism of non-hyperandrogenic women.

Key words: C-peptide/GnRHa/insulin/ovary/PCOS

3 To whom correspondence should be addressed


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