Human Reproduction, Vol. 14, No. 5, 1190-1193,
May 1999
© 1999 European Society of Human Reproduction and Embryology
Main inhibitor of follicle stimulating hormone in the luteal–follicular transition: inhibin A, oestradiol, or inhibin B?
1 INSERM U 342, Hôpital Saint-Vincent-de-Paul,82 av Denfert-Rochereau, 75014 Paris and 2 Service d'Endocrinologie, Hôpital Saint-Antoine, Paris, France
The roles of oestradiol, inhibin A and inhibin B in the luteal–follicular transition were assessed by means of specific assays. Six premenopausal women were studied during a control and then a cycle treated with percutaneous oestradiol 0.1 mg/day from day 10 after the luteinizing hormone (LH) surge until day 4 of the following cycle. Inhibin A concentrations decreased similarly in control and treated cycles from day –5 to day 2, then increased in control cycle to 23.3 ± 3.4 pg/ml on day 10 (mean ± SEM). They remained low until day 5 in treated cycles and were lower than controls on day 10 (P < 0.01). Follicle stimulating hormone (FSH) concentrations increased on day 1 in controls and on day 5 in treated cycles when oestradiol concentration fell abruptly. Inhibin B concentrations remained low until day 1 in controls and day 4 in treated cycles. In both, inhibin B concentrations increased 1 day after FSH, peaking at 160 pg/ml. FSH concentrations began to plateau when inhibin B concentrations were >100 pg/ml and oestradiol concentrations below 200 pmol/l. These data suggest that inhibin A is not responsible for FSH suppression in the luteal phase and that the negative control of FSH shifts from oestradiol in the luteal phase to inhibin B in the mid-follicular phase.
Key words: FSH/inhibin A/inhibin B/menstrual cycle/oestradiol
3 To whom correspondence should be addressed
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