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Human Reproduction, Vol. 14, No. 5, 1324-1327, May 1999
© 1999 European Society of Human Reproduction and Embryology

Case Report:Prenatal sonographic diagnosis of a fetal renal mesoblastic nephroma occurring after transfer of a cryopreserved embryo

Hiroaki Shibahara, Mizumi Mitsuo, Kazuya Fujimoto, Jyunko Muranaka, Hideaki Sawai, Takefumi Bessho, Minoru Shigeta and Koji Koyama1

Department of Obstetrics and Gynecology, Hyogo College of Medicine, 1–1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan

Here we report the first case of prenatally diagnosed fetal renal mesoblastic nephroma occurring after transfer of a cryopreserved embryo. A 37 year old woman, having immunological infertility, was treated by in-vitro fertilization (IVF) and embryo transfer. Following unsuccessful IVF using fresh embryos, the patient conceived after transfer of cryopreserved–thawed embryos. The chromosomal analysis identified a normal karyotype at 16 weeks' gestation when amniocentesis was performed. The pregnancy course was uneventful until 28 weeks' gestation when polyhydramnios associated with fetal renal tumour was detected using ultrasonography. A male infant weighing 2564 g was born via Caesarean section at 34 weeks' gestation. A left nephrectomy was performed 5 days after delivery and the tumour was identified histologically as a mesoblastic nephroma. The postoperative course was uncomplicated to this point.

Key words: : embryo cryopreservation/in-vitro fertilization/prenatal diagnosis/renal mesoblastic nephroma

1 To whom correspondence should be addressed


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