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Human Reproduction, Vol. 14, No. 6, 1431-1434, June 1999
© 1999 European Society of Human Reproduction and Embryology

Recombinant follicle stimulating hormone stimulation in poor responders with normal basal concentrations of follicle stimulating hormone and oestradiol: improved reproductive outcome

F. Raga1,2,4, F. Bonilla-Musoles1,2,3, E.M. Casañ1,2,3 and F. Bonilla1,2

1 Center for Obstetrics and Gynecology, 2 Department of Obstetrics and Gynecology, University of Valencia School of Medicine and 3 Hospital Clínico Universitario, Valencia, Spain

A total of 30 young infertile patients who exhibited a poor response in two previous consecutive cycles, despite having normal basal follicle stimulating hormone (FSH) and oestradiol concentrations, were invited to participate in a prospective randomized study comparing the clinical efficacy of recombinant (rFSH) and urinary (uFSH) follicle stimulating hormone. An evaluation of the total dose used (3800 IU versus 4600 IU, P < 0.05) and duration of treatment (10.2 days versus 13.2 days, P < 0.05) showed a significantly shorter treatment period as well as a significantly lower total dose of FSH required to induce ovulation successfully in the group of patients treated with rFSH. Significantly more oocytes (7.2 versus 5.6, P < 0.05) as well as mature oocytes (5.9 versus 3.2, P < 0.01) were retrieved after rFSH treatment. In addition, significantly more good quality embryos were obtained (3.4 versus 1.8, P < 0.05) in the group of patients treated with rFSH and, as a result, higher pregnancy (33 versus 7%, P < 0.01) and implantation (16 versus 3%, P < 0.01) rates were achieved in these patients. It is concluded that rFSH is more effective than uFSH in inducing multifollicular development and achieving pregnancy in young low responders.

Key words: poor responder/recombinant FSH/reproductive performance

4 To whom correspondence should be addressed at: Center for Obstetrics and Gynecology, Navarro Reverter 11–1, 46004 Valencia, Spain


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