Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (13)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Eldar-Geva, T.
Right arrow Articles by Trounson, A.O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eldar-Geva, T.
Right arrow Articles by Trounson, A.O.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 14, No. 6, 1461-1466, June 1999
© 1999 European Society of Human Reproduction and Embryology

Cumulative pregnancy and live birth rates in women with antiphospholipid antibodies undergoing assisted reproduction

T. Eldar-Geva1,2,3, C. Wood1, N. Lolatgis1, L. Rombauts1, G. Kovacs1, J. Fuscaldo1 and A.O. Trounson2

1 Monash IVF, Epworth Hospital, Richmond 3121, 2 Centre for Early Human Development, Monash University, Clayton 3168, Victoria, Australia

The aims of this study were to investigate the influence of antiphospholipid antibodies (APA) on cumulative pregnancy and live-birth rates in patients undergoing assisted reproductive treatment. Serum samples from 173 patients were collected prior to initiation treatment cycle and tested by enzyme-linked immunosorbent assay (ELISA) for the presence of immunoglobulin (Ig)G, IgM and IgA against cardiolipin, phosphoserine, phosphoethanolamine, phosphoinositol, phosphatidic acid, and phosphoglycerol. Fifty-six samples from patients who had at least two failed cycles by assisted reproductive treatment were also tested by a bioassay for the presence of lupus anticoagulants. Both cumulative pregnancy and live birth rates were not affected by the presence of any specific or any number of seropositive APA. There was no association between multiple assisted reproductive treatment failures and APA seropositivity. Neither the serum concentration of any of the 18 APA, nor the number of positive APA was correlated with the number of assisted reproductive treatment failed cycles or affected the probability of pregnancy. No patient was found to be positive for lupus anticoagulants. Using life table analyses, which has been recognized as the most appropriate method available to analyse assisted reproductive treatment results, we conclude that there is no relationship between circulating APA and assisted reproductive treatment outcome. APA do not affect the early process of implantation or maintenance of pregnancy among assisted reproductive treatment patients.

Key words: antiphospholipid antibodies/assisted reproductive treatment/cumulative live birth rate/cumulative pregnancy rate/implantation failure

3 To whom correspondence should be addressed


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
E.J. Margalioth, A. Ben-Chetrit, M. Gal, and T. Eldar-Geva
Investigation and treatment of repeated implantation failure following IVF-ET
Hum. Reprod., December 1, 2006; 21(12): 3036 - 3043.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. S. Ghazeeri and W. H. Kutteh
Immunological testing and treatment in reproduction: frequency assessment of practice patterns at assisted reproduction clinics in the USA and Australia
Hum. Reprod., October 1, 2001; 16(10): 2130 - 2135.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Eldar-Geva and A. O. Trounson
Antiphospholipid antibodies and reproductive failure
Hum. Reprod., August 1, 2000; 15(8): 1875 - 1876.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Stern, G. Baker, and L.W. Chamley
Antiphospholipid antibodies and reproductive failure
Hum. Reprod., July 1, 2000; 15(7): 1649 - 1650.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.