Human Reproduction, Vol. 14, No. 6, 1619-1623,
June 1999
© 1999 European Society of Human Reproduction and Embryology
Relationship between maternal serum vascular endothelial growth factor concentration in early pregnancy and fetal and placental growth
1 Obstetrics and Gynaecology and 2 Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton SO16 5YA, UK
Vascular endothelial growth factor (VEGF) has important effects on endothelial cells increasing cell proliferation, permeability and nitric oxide production; concentrations of VEGF in the maternal serum increase during the first 10 weeks of pregnancy. In this study, the relationship of maternal serum VEGF with maternal health during pregnancy and with fetal and placental size at mid-pregnancy and at term was investigated. Serum was obtained from 539 Caucasian women with singleton pregnancies between 8 and 20 weeks of pregnancy (mean 14 weeks). Total serum VEGF concentrations were measured by direct competitive radioimmunoassay. Fetal size and placental volume were measured by ultrasound between 16 and 20 weeks gestation. Birthweight, placental weight and anthropometric measurements of the baby were obtained after delivery. Serum VEGF concentrations were found to be higher in women with a lower weight before pregnancy (P = 0.01) and in those carrying a female fetus (P = 0.002). VEGF concentrations were positively correlated with placental volume (r = 0.17, P = 0.0001) but not with fetal size between 16 and 20 weeks gestation. Serum VEGF concentrations were positively correlated with both birthweight (r = 0.10, P = 0.02) and placental weight at delivery (r = 0.13, P = 0.003). The data presented support the view that VEGF may be one of the factors involved in mediating the maternal cardiovascular adaptation to pregnancy.
Key words: birthweight/placental volume/VEGF
3 To whom correspondence should be addressed at: Obstetrics and Gynaecology (815), University of Southampton, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
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