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Human Reproduction, Vol. 14, No. 7, 1703-1706, July 1999
© 1999 European Society of Human Reproduction and Embryology

Recurrent empty follicle syndrome successfully treated with recombinant human chorionic gonadotrophin: Case report

Joana Peñarrubia, Juan Balasch1, Francisco Fábregues, Montserrat Creus, Salvadora Cívico and Juan A.Vanrell

Institut Clínic of Gynecology, Obstetrics and Neonatology; Faculty of Medicine-University of Barcelona, Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Suynyer (IDIBAPS), C/Casanova 143, 08036 Barcelona, Spain

We report a case of a patient with polycystic ovary syndrome and primary infertility who was admitted to our in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) programme because of her partner's severe oligozoospermia and asthenozoospermia. Ovarian stimulation was accomplished in the three treatment cycles using gonadotrophin therapy after a dual approach with ovarian suppression using oral contraceptive pills followed by gonadotrophin-releasing hormone agonist therapy. Oocyte retrieval was unsuccessful in the first two treated cycles despite the fact that human chorionic gonadotrophin (HCG) from three different batches was used. In the third treatment cycle, recombinant HCG was used and five oocytes were retrieved. This is the first report of recurrent empty follicle syndrome despite the use of different batches of commercially available urinary HCG, and of its successful treatment using recombinant HCG.

Key words: empty follicle syndrome/HCG/in-vitro fertilization/recombinant gonadotrophins/recombinant HCG

1 To whom correspondence should be addressed


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