Human Reproduction, Vol. 14, No. 9, 2236-2241,
September 1999
© 1999 European Society of Human Reproduction and Embryology
Recombinant human follicle stimulating hormone versus human menopausal gonadotrophin induction: effects in mature follicle endocrinology
1 Centre d'Assistance Médicale à la Procréation, Service de Gynécologie–Obstétrique, Centre Hospitalier Universitaire de Limoges, Limoges, 2 Service de Biochimie et Biologie Moléculaire et Faculté de Médecine, Limoges, France
To investigate follicular effects of recombinant human follicle stimulating hormone (rhFSH) induction on women with polycystic ovary syndrome (PCOS), steroid content was compared in mature follicles obtained using a long luteinizing hormone-releasing hormone agonist plus rhFSH or human menopausal gonadotrophin (HMG) in PCOS women and controls participating in an in-vitro fertilization programme. Follicular fluids (144 samples) were collected at oocyte retrieval by individual selective aspiration. Oocyte maturity and fecundability were assessed. Plasma and intrafollicular 17ß-oestradiol, progesterone, testosterone concentrations were assayed individually. No significant difference was seen in oocyte maturity and fecundability between PCOS and controls following rhFSH, or between PCOS rhFSH and HMG group. 17ß-oestradiol, testosterone and progesterone concentrations were lower in PCOS follicular fluid following rhFSH than HMG but the difference was not significant. Progesterone concentration, 17ß-oestradiol/progesterone, 17ß-oestradiol/testosterone were significantly different between the two induction groups, for PCOS fertilized oocyte follicles (P = 0.01, P < 0.05 and P < 0.05 respectively). Steroidogenic enzymatic activity seems to be regulated in healthy follicular cells in PCOS as well as in normal patients upon ovarian induction. Following rhFSH, higher PCOS follicular progesterone concentrations leading to a theoretically increased fecundability could suggest that recombinant FSH is a better inducer which needs to be confirmed.
Key words: follicular sex steroids/human menopausal gonadotrophin/human recombinant FSH/in-vitro fertilization/polycystic ovary syndrome
3 To whom correspondence should be addressed at: Centre d'AMP, Service de Gynécologie–Obstétrique, CHU Dupuytren, Avenue Martin Luther King, 87042 Limoges cedex, France
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