Human Reproduction, Vol. 14, No. 9, 2268-2273,
September 1999
© 1999 European Society of Human Reproduction and Embryology
The influence of donated gametes on the incidence of hypertensive disorders of pregnancy
1 Assisted Conception Unit, St James's University Hospital, 2 Assisted Conception Unit, The General Infirmary at Leeds, 3 Department of Obstetrics and Gynaecology, St James's University Hospital and 4 Medical Statistics, Department of Research and Development, St James's University Hospital, Leeds, UK
Pregnancies achieved from oocyte, sperm or embryo donation are unique, since they have resulted from donor gametes that are immunologically foreign to the mother. Thus, studying the obstetric outcome of such pregnancies may shed some light on the pathophysiology of preeclampsia, particularly in women conceiving with donated embryos, since the entire fetal genome is allogenic in these pregnancies. In this retrospective cohort study, a total of 144 women were studied. Of these, 72 were infertility patients who had conceived as a result of sperm, ovum or embryo donation and the other 72 women were age- and parity-matched control patients who became pregnant with their own gametes, either spontaneously, or following intrauterine insemination with their partner's spermatozoa. Study patients were divided into three groups depending on the origin of the donated gametes. Group 1 consisted of pregnancies achieved by intrauterine insemination with washed donor spermatozoa (n = 33). Group 2 included women who conceived using donated oocytes (n = 27) and group 3 consisted of women who conceived as a result of embryo donation (n = 12). The incidence of pregnancy-induced hypertension in the donated gametes study group was 12.5% (9/72) compared with 2.8% (2/72) in the control group. In addition, pre-eclampsia was diagnosed in 18.1% (13/72) of the donated gametes study group compared to 1.4% (1/72) in the age- and parity-matched controls. The increased incidence of gestational hypertension in pregnancies resulting from donated gametes gives evidence for a maternal genetic component, with an equally strong fetal influence, in the complicated aetiology of gestational hypertension, and pre-eclampsia in particular.
Key words: donor insemination/embryo donation/oocyte donation/pre-eclampsia/pregnancy-induced hypertension
5 To whom correspondence should be addressed at: The Assisted Conception Unit, St James's University Hospital, Leeds LS9 7TF, UK
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. A. Robertson, L. R. Guerin, J. J. Bromfield, K. M. Branson, A. C. Ahlstrom, and A. S. Care Seminal Fluid Drives Expansion of the CD4+CD25+ T Regulatory Cell Pool and Induces Tolerance to Paternal Alloantigens in Mice Biol Reprod, May 1, 2009; 80(5): 1036 - 1045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Nelson Primary Ovarian Insufficiency N. Engl. J. Med., February 5, 2009; 360(6): 606 - 614. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Bodri, V. Vernaeve, F. Figueras, R. Vidal, J.J. Guillen, and O. Coll Oocyte donation in patients with Turner's syndrome: a successful technique but with an accompanying high risk of hypertensive disorders during pregnancy Hum. Reprod., March 1, 2006; 21(3): 829 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Saftlas, N. Logsden-Sackett, W. Wang, R. Woolson, and M. B. Bracken Work, Leisure-Time Physical Activity, and Risk of Preeclampsia and Gestational Hypertension Am. J. Epidemiol., October 15, 2004; 160(8): 758 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Soderstrom-Anttila, S. Vilska, S. Makinen, T. Foudila, and A.-M. Suikkari Elective single embryo transfer yields good delivery rates in oocyte donation Hum. Reprod., September 1, 2003; 18(9): 1858 - 1863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Saftlas, R. J. Levine, M. A. Klebanoff, K. L. Martz, M. G. Ewell, C. D. Morris, and B. M. Sibai Abortion, Changed Paternity, and Risk of Preeclampsia in Nulliparous Women Am. J. Epidemiol., June 15, 2003; 157(12): 1108 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Paulson, R. Boostanfar, P. Saadat, E. Mor, D. E. Tourgeman, C. C. Slater, M. M. Francis, and J. K. Jain Pregnancy in the Sixth Decade of Life: Obstetric Outcomes in Women of Advanced Reproductive Age JAMA, November 13, 2002; 288(18): 2320 - 2323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Sheffer-Mimouni, S. Mashiach, J. Dor, D. Levran, and D. S. Seidman Factors influencing the obstetric and perinatal outcome after oocyte donation Hum. Reprod., October 1, 2002; 17(10): 2636 - 2640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Dawson, P. S. Parfrey, D. Hefferton, E. L. Dicks, M. J. Cooper, D. Young, and P. A. Marsden Familial Risk of Preeclampsia in Newfoundland: A Population-Based Study J. Am. Soc. Nephrol., July 1, 2002; 13(7): 1901 - 1906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Soderstrom-Anttila, T. Foudila, U.-R. Ripatti, and R. Siegberg Embryo donation: outcome and attitudes among embryo donors and recipients Hum. Reprod., June 1, 2001; 16(6): 1120 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Hall, W. L. Noble, S. W. Lindow, and E. A. Masson Long-term sexual co-habitation offers no protection from hypertensive disease of pregnancy Hum. Reprod., February 1, 2001; 16(2): 349 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kristiansson and J.X. Wang Reproductive hormones and blood pressure during pregnancy Hum. Reprod., January 1, 2001; 16(1): 13 - 17. [Abstract] [Full Text] [PDF]
|
|