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Human Reproduction, Vol. 14, No. suppl_1, pp. 1-23, 1999
© 1999 European Society of Human Reproduction and Embryology

Analysis of medical treatment of male infertility

A. Kamischke and E. Nieschlag1

Institute of Reproductive Medicine of the University (WHO Collaborating Centre for Research in Human Reproduction) Münster, Germany

Correspondence: 1To whom correspondence should be addressed at: Institute of Reproductive Medicine of the University, Domagkstrasses 11, D-48129 Münster, Germany: e-mail: Nieschl{at}uni-muenster.de

Since the first injection of a single spermatozoon into the cytoplasm of an oocyte (intracytoplasmic sperm injection, ICSI), this method has become the most successful means of treating male infertility. Even for patients long considered untreatable, a chance of paternity has become reality. Using not only ejaculated but also testicular spermatozoa, pregnancies have been achieved in the partners of patients who had never had a chance previously, including even cases with Klinefelter syndrome. However, despite the tremendous success of ICSI, most couples would prefer to conceive offspring naturally. Therefore we review the effectiveness of current conventional treatments for male infertility and analyse the chances of infertile couples to conceive spontaneously.

Key words: fertility prognosis/hypogonadotrophic hypogonadism/male infertility/meta-analysis/randomized clinical trials


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