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Human Reproduction, Vol. 14, No. suppl_1, pp. 24-37, 1999
© 1999 European Society of Human Reproduction and Embryology

Genetics of male subfertility: consequences for the clinical work-up

Wolfgang Küpker1,5, Eberhard Schwinger2, Olaf Hiort3, Michael Ludwig1, Nikos Nikolettos1, Peter N. Schlegel4 and Klaus Diedrich1

1 Department of Obstetrics and Gynecology, Medical University Lübeck Ratzeburger Allee 160, 23538 Lübeck, Germany 2 Institute of Human Genetics, Medical University Lübeck Ratzeburger Allee 160, 23538 Lübeck, Germany 3 Department of Pediatrics, Medical University Lübeck Ratzeburger Allee 160, 23538 Lübeck, Germany 4 James Buchanan Brady Foundation, Department of Urology, New York Hospital — Cornell Medical Center New York, USA

Correspondence: 5To whom correspondence should be addressed

Major principles of genetic failures, chromosomal alterations and the most common syndromes associated with male subfertility should be taken into account before medical therapy and sophisticated techniques of assisted fertilization are applied to help a couple conceive. This review addresses the most common genetic reasons for male subfertility or infertility with special regard to the importance for the clinical work-up in daily routine and the potential risks for the conceptus.

Key words: androgen receptor/chromosome disorders/genetics/male subfertility/Y deletions


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