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Human Reproduction, Vol. 14, No. suppl_2, pp. 107-111, 1999
© 1999 European Society of Human Reproduction and Embryology

Ovarian stimulation and endometrial receptivity

Diana Valbuena1, Melinda Jasper1, José Remohí1,2, Antonio Pellicer1,2 and Carlos Simón1,2,3

1 Instituto Valenciano de Infertilidad Valencia, Spain 2 Department of Pediatrics, Obstetrics and Gynaecology Valencia, Spain

Correspondence: 3To whom correspondence should be addressed at: Calle Guardia Civil 23, Valencia 46020, Spain

Endometrial receptivity is a limiting step in the success of in-vitro fertilization (IVF). To investigate this issue, we selected a specific population of high responder patients in whom implantation was impaired, even when good quality embryos were transferred. We present a series of studies showing that high oestradiol concentrations on the day of human chorionic gonadotrophin (HCG) administration are detrimental to uterine receptivity. In addition, we suggest clinical strategies to improve endometrial receptivity in high responder patients using a step-down regimen.

Key words: embryo/endometrial receptivity/human implantation/oestradiol


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