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Human Reproduction, Vol. 15, No. 10, 2200-2204, October 2000
© 2000 European Society of Human Reproduction and Embryology

The use of whole rat embryo culture as a technique for investigating potential serum toxicity in recurrent miscarriage patients

Matthew J. Hewitt1,4, Margaret K. Pratten2, Lesley Regan3, Siobhan M. Quenby1 and Philip N. Baker1

1 School of Human Development and 2 School of Biomedical Sciences, University of Nottingham, UK and 3 Imperial College of Science and Technology, UK

Previously, the rat embryo model has been used as an experimental technique in investigations of the aetiology of idiopathic recurrent miscarriage. The aim of the present study was to validate it as a tool in the investigation of the aetiology of this condition. Subjects (n = 36) with a history of recurrent miscarriage were recruited from two dedicated recurrent miscarriage clinics and compared with control women with at least one previous pregnancy resulting in a live birth (n = 23). Serum from each woman was used as culture medium in the rat embryo model. Cultured embryos were scored for growth and differentiation. No statistical difference was found in any parameter between the two groups. Furthermore, patients from the recurrent miscarriage group whose serum demonstrated a trend towards lower scores, subsequently conceived and underwent uncomplicated pregnancies.

Key words: rat embryo model/recurrent miscarriage

4 To whom correspondence should be addressed at: School of Human Development, Division of Obstetrics and Gynaecology,City Hospital, Hucknall Road, Nottingham NG5 1PB, UK. E-mail: matthew.hewitt{at}nottingham.ac.uk


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