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Human Reproduction, Vol. 15, No. 12, 2455-2459, December 2000
© 2000 European Society of Human Reproduction and Embryology

Does blastocyst culture eliminate paternal chromosomal defects and select good embryos?

Inheritance of an abnormal paternal genome following ICSI

Subhasis Banerjee1, Scott Lamond, Aidan McMahon, Stuart Campbell and Geeta Nargund

Centre for Reproductive Medicine, Department of Obstetrics & Gynaecology, St. George's Hospital Medical School, Cranmer Terrace, University of London,London SW17 ORE, UK

Following intracytoplasmic sperm injection (ICSI), ~60–70% of oocytes are fertilized and of these embryos, ~45% withstand in-vitro culture conditions to produce healthy blastocysts. The efficiency of implantation of 2–4-cell embryos selected at the pronuclear stage and that of blastocysts are comparable. However, prolonged selection of embryos in vitro (4–5 days), has been proposed to eliminate chromosomal abnormalities, more specifically those inherited by defective spermatozoa. This hypothesis is based upon the assumption that the paternal genetic contribution is indispensable for blastocyst development. Here we examine this hypothesis and suggest that phenotypic manifestation of paternal genomic abnormalities might not occur prior to implantation. In addition to the parent-of-origin effect during embryogenesis, blastocyst transfer may not prevent the inheritance of genetic defects involving `male factor' loci.

Key words: abnormal paternal chromosomes/blastocyst culture/genomic imprinting/ICSI

1 To whom correspondence should be addressed.

This debate was previously published on Webtrack, September 11, 2000


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