Human Reproduction, Vol. 15, No. 3, 604-607,
March 2000
© 2000 European Society of Human Reproduction and Embryology
Incidence of cancer in children born after in-vitro fertilization
1 Centre for the Study of Mothers' and Children's Health, La Trobe University, 251 Faraday Street, Carlton, 3053, Victoria, 2 Australian Institute of Health and Welfare National Perinatal Statistics Unit, University of New South Wales, Sydney, 2031, NSW, 3 Reproductive Biology Unit, Royal Women's Hospital, Carlton, 3053, Victoria and 4 Monash IVF & Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Clayton, 3168, Victoria, Australia
Evaluation of the long-term health of children born using in-vitro fertilization (IVF) provides important information to clinicians and consumers. Until very recently, there have been no published data on the incidence of cancer in children conceived as a result of IVF, despite a number of case reports of neuroblastoma in children conceived using fertility drugs. This study used a record-linkage cohort design to investigate the incidence of cancer in children born after IVF. The study included all conceptions using assisted reproductive technologies between 1979 and 1995 at two clinics in Victoria, Australia that resulted in a live birth. Data on births were linked with a population-based cancer registry to determine the number of cases of cancer that occurred. The standardized incidence ratio (SIR) was calculated by comparing the observed number of cases to the expected number of cases. The final cohort included 5249 births. The median length of follow-up was 3 years, 9 months (range 0–15 years). In all, 4.33 cases of cancer were expected and six were observed, giving a SIR of 1.39 (95% CI 0.62–3.09). This study found that children conceived using IVF and related procedures did not have a significantly increased incidence of cancer in comparison to the general population.
Key words: cancer incidence/children/IVF/long-term follow-up
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