Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (40)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Wong, K.S.
Right arrow Articles by Ho, P.C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wong, K.S.
Right arrow Articles by Ho, P.C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 15, No. 3, 709-712, March 2000
© 2000 European Society of Human Reproduction and Embryology

A comparison of two regimens of intravaginal misoprostol for termination of second trimester pregnancy: a randomized comparative trial

K.S. Wong1,3, C.S.W. Ngai2, E.L.K. Yeo1, L.C.H. Tang1 and P.C. Ho2

1 Department of Obstetrics and Gynaecology, Kwong Wah Hospital and 2 Department of Obstetrics and Gynaecology, Queen Mary Hospital, Hong Kong SAR, China

A prospective randomized trial was conducted in 148 women to compare the efficacy of two regimens of vaginal misoprostol for termination of second trimester pregnancy. Women aged 16–40 years requesting termination of second trimester pregnancy were randomized into two groups. Women in group 1 were given vaginal misoprostol 400 µg every 3 h for a maximum of five doses in 24 h. Women in group 2 were given vaginal misoprostol 400 µg every 6 h for a maximum of three doses in 24 h. If women did not abort in 24 h, the same regimen was repeated. The median induction–abortion interval in group 1 (15.2 h) was significantly shorter (P < 0.01) than that in the group 2 (19.0 h). The percentage of women who achieved successful abortion within 48 h in group 1 (90.5%) was also significantly higher (P < 0.02) than that in group 2 (75.7%). The incidence of fever was more common in group 1 (P = 0.01). It is concluded that the regimen of vaginal misoprostol 400 µg every 3 h with maximum of five doses in 24 h was more effective than the regimen of misoprostol every 6 h in termination of second trimester pregnancy.

Key words: misoprostol/second trimester abortion

3 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Kwong Wah Hospital, 25 Waterloo Road, Kowloon, Hong Kong SAR, China


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
O. S. Tang, H. Schweer, S. W.H. Lee, and P. C. Ho
Pharmacokinetics of repeated doses of misoprostol
Hum. Reprod., August 1, 2009; 24(8): 1862 - 1869.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Chai, O.S. Tang, Q.Q. Hong, Q.F. Chen, L.N. Cheng, E. Ng, and P.C. Ho
A randomized trial to compare two dosing intervals of misoprostol following mifepristone administration in second trimester medical abortion
Hum. Reprod., February 1, 2009; 24(2): 320 - 324.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H. von Hertzen, G. Piaggio, D. Wojdyla, N. T. M. Huong, L. Marions, G. Okoev, A. Khomassuridze, A. Kereszturi, S. Mittal, R. Nair, et al.
Comparison of vaginal and sublingual misoprostol for second trimester abortion: randomized controlled equivalence trial
Hum. Reprod., January 1, 2009; 24(1): 106 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
S. Lalitkumar, M. Bygdeman, and K. Gemzell-Danielsson
Mid-trimester induced abortion: a review
Hum. Reprod. Update, January 1, 2007; 13(1): 37 - 52.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
O. S. Tang, C. C.W. Chan, A. S.Y. Kan, and P. C. Ho
A prospective randomized comparison of sublingual and oral misoprostol when combined with mifepristone for medical abortion at 12-20 weeks gestation
Hum. Reprod., November 1, 2005; 20(11): 3062 - 3066.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
B. Yilmaz, S. Kelekci, I. E. Ertas, S. Kahyaoglu, M. Ozel, N. Sut, and N. Danisman
Misoprostol moistened with acetic acid or saline for second trimester pregnancy termination: a randomized prospective double-blind trial
Hum. Reprod., November 1, 2005; 20(11): 3067 - 3071.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
Y.-S. Chong, S. Chua, and S. Arulkumaran
Sublingual misoprostol for first trimester termination of pregnancy: safety concerns
Hum. Reprod., October 1, 2002; 17(10): 2777 - 2777.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
O. S. Tang, B.Y. Miao, S. W.H. Lee, and P. C. Ho
Pilot study on the use of repeated doses of sublingual misoprostol in termination of pregnancy up to 12 weeks gestation: efficacy and acceptability
Hum. Reprod., March 1, 2002; 17(3): 654 - 658.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. K. Jain and D. R. Mishell Jr
Misoprostol regimens for termination of second trimester pregnancy
Hum. Reprod., February 1, 2001; 16(2): 393 - 393.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.