Human Reproduction, Vol. 15, No. 4, 810-816,
April 2000
© 2000 European Society of Human Reproduction and Embryology
Transmission risk of hepatitis C virus in assisted reproductive techniques
1 Laboratoire de Biologie de la Reproduction and 2 Laboratoire de Virologie, Hôpital Nord, 42055 Saint Etienne, 3 Laboratoire de Virologie, Domaine Rockefeller, 69373 Lyon cedex 08, 4 Laboratoire de Biologie de la Reproduction et du Développement and 5 Service de Gastro entérologie, Hôpital Edouard Herriot, Place d'Arsonval, 69437 Lyon, France
Medical assistance for procreation in a couple where one or both parents has hepatitis C viral infection (HCV) raises the issue of the transmission of the infection to the baby and/or of possible contamination of both the technicians and the gametes or embryos from virus-free parents in the laboratory. It becomes essential to assess transmission risk in assisted reproductive techniques in order to define clearly the management of couples according to their viral status. To define the HCV transmissibility risk in assisted reproduction related to the presence of virus in semen from infected infertile men, HCV RNA detection was performed in sera, and semen and sperm fractions obtained after Percoll gradient centrifugation. HCV RNA was detected in 5% (2/39) of the semen samples tested: in the raw semen, in the seminal fluid and in the cell pellet but never after Percoll selection. According to these results, we suggest a strategy for HCV-infected infertile men who need assistance for procreation.
Key words: assisted reproductive techniques/hepatitis C virus/viral screening
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