Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (46)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Felberbaum, R.E.
Right arrow Articles by Diedrich, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Felberbaum, R.E.
Right arrow Articles by Diedrich, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 15, No. 5, 1015-1020, May 2000
© 2000 European Society of Human Reproduction and Embryology

Ovarian stimulation for assisted reproduction with HMG and concomitant midcycle administration of the GnRH antagonist Cetrorelix according to the multiple dose protocol: a prospective uncontrolled phase III study

R.E. Felberbaum1,4, C. Albano2, M. Ludwig1, H. Riethmüller-Winzen3, M. Grigat3, P. Devroey2, K. Diedrich1 and on behalf of the European Cetrorelix Study Group,*

1 Department of Obstetrics and Gynaecology at the Medical University of Lübeck, Germany, 2 Centre for Reproductive Medicine of the Dutch-Speaking Free University of Brussels, Belgium and 3 ASTA-Medica AG, Frankfurt/Main, Germany

A total of 346 women with normal ovulatory function was stimulated with human menopausal gonadotrophins (HMG) to attain ovarian stimulation for IVF or intracytoplasmic sperm injection (ICSI). Stimulation with HMG started on cycle day 2 or 3. After 6 days of stimulation, Cetrorelix in its minimum effective multiple dose of 0.25 mg/day, was administered daily until induction of ovulation. In total, 333 patients (96.2%) reached the day of HCG administration, and 324 (93.6%) underwent oocyte retrieval. A mean of 25.2 ampoules of HMG was applied for a mean of 10.4 days. Cetrorelix was administered for a mean time lapse of 5.7 days. The mean normal fertilization rate was 60% in the IVF group and 59% in the ICSI group. Seventy pregnancies were attained, reflecting an ongoing clinical pregnancy rate of 24% per transfer. The ongoing clinical implantation rate was 11.4%. Only three cases of raised luteinizing hormone (LH) (>=10 IU/l) with increased progesterone secretion (>=1 ng/ml) were observed after initiation of Cetrorelix administration, reflecting an incidence of premature luteinization of 0.9%. The abortion rate was 17%. The incidence of severe ovarian hyperstimulation syndrome (World Health Organization grade III) was as low as 0.6%.

Key words: Cetrorelix/gonadotrophin-releasing hormone antagonists/human menopausal gonadotrophins/ovarian stimulation

4 To whom correspondence should be addressed

* Prof. Dr K.H.R.Diedrich and Dr med. R.E.Felberbaum, Lübeck, Germany; Prof. Dr M.Breckwoldt, Dr med. C.Keck and Dr med. D.Vogelsang, Freiburg, Germany; Prof. Dr H. van der Ven, Prof. Dr D. Krebs, Dr D.M.Indefrei and Dr C.C.Dibelius, Bonn, Germany; Dr E.Siebzehnrübl and Prof. Dr N. Lang, Erlangen, Germany; Prof. Dr F.Fischl and Dr A.Obruca, Wien, Vienna, Austria; Prof. Dr W.Urdl, Dr H.Auner and Dr A.Giuliani, Graz, Austria; Prof. Dr J.-R.Zorn, Dr N.Ledee and Dr A.Coffineau, Paris, France; Prof. Dr B.C.Tarlatzis, Thessaloniki, Greece; Prof. Dr P.G.Crosignani and Dr G.Ragni, Milan, Italy; Prof. Dr M.Filicori, Prof. Dr C.Flamigni and Dr G.E.Cognigni, Bologna, Italy; Prof. Dr R.Ron-El, Zerefin, Israel; Dr P.N.Barri and Dr F.Martinez, Barcelona, Spain; Dr V.von Düring and Prof. Dr A.Sunde, Trondheim, Norway.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
B. Asimakopoulos, F. Koster, R. Felberbaum, S. Al-Hasani, K. Diedrich, and N. Nikolettos
Cytokine and hormonal profile in blood serum and follicular fluids during ovarian stimulation with the multidose antagonist or the long agonist protocol
Hum. Reprod., December 1, 2006; 21(12): 3091 - 3095.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
I. E. Messinis
Ovarian feedback, mechanism of action and possible clinical implications
Hum. Reprod. Update, September 1, 2006; 12(5): 557 - 571.
[Abstract] [Full Text] [PDF]

Home page
 J Clin PharmacolHome page
N. V. Nagaraja, B. Pechstein, K. Erb, C. Klipping, R. Hermann, M. Locher, and H. Derendorf
Pharmacokinetic/Pharmacodynamic Modeling of Luteinizing Hormone (LH) Suppression and LH Surge Delay by Cetrorelix after Single and Multiple Doses in Healthy Premenopausal Women
J. Clin. Pharmacol., March 1, 2003; 43(3): 243 - 251.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J.B. Engel, M. Ludwig, R. Felberbaum, C. Albano, P. Devroey, and K. Diedrich
Use of cetrorelix in combination with clomiphene citrate and gonadotrophins: a suitable approach to 'friendly IVF'?
Hum. Reprod., August 1, 2002; 17(8): 2022 - 2026.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. A. Garcia-Velasco, V. Isaza, C. Vidal, A. Landazabal, J. Remohi, C. Simon, and A. Pellicer
Human ovarian steroid secretion in vivo: effects of GnRH agonist versus antagonist (cetrorelix)
Hum. Reprod., December 1, 2001; 16(12): 2533 - 2539.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.