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Human Reproduction, Vol. 15, No. 5, 999-1002, May 2000
© 2000 European Society of Human Reproduction and Embryology

Empty follicle syndrome: evidence for recurrence

T.G. Zreik, J.A. Garcia-Velasco1, T.M. Vergara, A. Arici, D. Olive and E.E. Jones

Yale University School of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, 333 Cedar Street, New Haven, CT 06520, USA

The empty follicle syndrome (EFS) is a frustrating condition in which no oocytes are retrieved in an IVF cycle. Although this is an infrequent event in IVF patients, the economic consequences as well as the emotional frustration of a cancelled cycle due to the inability to obtain oocytes are enormous. The mechanisms responsible for EFS remain obscure, though many hypotheses have been put forward ranging from dysfunctional folliculogenesis to a drug-related problem. We found that the EFS is a rare event (1.8% of oocyte retrievals) but with profound implications for counselling the couple about their future reproductive performance. The chances of recurrence of EFS increase with the age of the patient (24% recurrence rate for the 35–39 year age group, and 57% for those over 40 years). We postulate that ovarian ageing, through altered folliculogenesis, may be implicated in the aetiology of EFS and its recurrence.

Key words: empty follicle syndrome/failed oocyte retrieval/human chorionic gonadotrophin/IVF/recurrence

1 To whom correspondence should be addressed at: IVI-Madrid,C/Santiago de Compostela 88, 28035 Madrid, Spain


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