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Human Reproduction, Vol. 15, No. 6, 1345-1349, June 2000
© 2000 European Society of Human Reproduction and Embryology

Angiotensin II in human seminal fluid

Orla A. O'Mahony1,3, O. Djahanbahkch2, T. Mahmood2, J.R. Puddefoot1 and G.P. Vinson1

1 Division of Biomedical Sciences, and 2 Academic Department of Obstetrics and Gynaecology and Reproductive Physiology, St Bartholomew's and Royal London School of Medicine and Dentistry, Queen Mary & Westfield College, London E1 4NS, UK

The renin–angiotensin system (RAS) and angiotensin II are important in sperm function and male fertility. Angiotensin II type I (AT1) receptors have been identified in developing and ejaculated human spermatozoa, and angiotensin can stimulate sperm motility, the acrosome reaction and binding to the zona pellucida. However, there is little information on the availability of the hormone to spermatozoa during the reproductive process. Seminal plasma and blood plasma obtained from normal and subfertile subjects was extracted, and angiotensin content was analysed by radioimmunoassay. Values obtained for blood angiotensin II were within the normal range at 16.0 ± 3.1 pg/ml (mean ± SEM). Values for seminal plasma were usually 3–5 fold higher, at 51.6 ± 9.3 pg/ml (n = 34, P < 0.0001). High performance liquid chromatography analysis showed that ~80% of the immunoreactive angiotensin was attributable to angiotensin II itself. However, seminal plasma angiotensin II concentrations were not correlated with blood angiotensin II, sperm concentration or sperm motility. The results show that immunoreactive angiotensin from a source other than the circulation is available to spermatozoa in human ejaculates. The results are consistent with the concept that angiotensin II has an important role in male fertility.

Key words: angiotensin II/blood/human/seminal fluid

3 To whom correspondence should be addressed.E-mail: O.A.OMahony{at}qmw.ac.uk


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