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Human Reproduction, Vol. 15, No. 7, 1629-1631, July 2000
© 2000 European Society of Human Reproduction and Embryology

Is trophoblastic thickness at the embryonic implantation site a new sign of negative evolution in first trimester pregnancy?

J. Bajo, F.J. Moreno-Calvo1, L. Martinez-Cortés, F.J. Haya and J. Rayward

Department of Obstetrics and Gynecology, Hospital Universitario Getafe, 28905 Madrid, Spain

In this study a new sign to evaluate the evolution of pregnancy is described: the trophoblastic thickness at the embryonic implantation site. A prospective, observational study of 592 normal pregnancies with no known risk factors was carried out from January 1998 to February 1999. Serial ultrasound scans were performed from week 5 to week 12 of pregnancy. Trophoblastic thickness was measured at the embryonic implantation site to determine the significance of a difference in gestational age in weeks and a trophoblastic thickness of >=3 mm in predicting poor prognosis in pregnancy outcome. The sensitivity of this sign in the prediction of spontaneous abortion was 82%, the specificity was 93%, the positive predictive value was 63% and the negative predictive value was 97%.

Key words: early pregnancy/spontaneous abortion/trophoblast

1 To whom correspondence should be addressed at: Servicio de Obstetricia y Ginecología, Hospital Universitario de Getafe, Ctra. Madrid-Toledo, Km 12 500, 28905 Madrid, Spain. E-mail: fmorenoc{at}sego.es


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