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Human Reproduction, Vol. 15, No. 8, 1698-1702, August 2000
© 2000 European Society of Human Reproduction and Embryology

Three-dimensional endometrial volume estimation as a predictor of pituitary down-regulation in an IVF–embryo transfer programme

C. Yaman1,3, T. Ebner1, M. Sommergruber1, J. Hartl1, W. Pölz2 and G. Tews1

1 Women's General Hospital, IVF Unit, Lederergasse 47 and 2 University of Linz, Department for Statistics, Altenbergstr. 69, A-4040 Linz, Austria

To examine the role of three-dimensional (3D) volume estimation in predicting pituitary down-regulation in an IVF–embryo transfer programme, 46 women were treated with buserelin acetate for down-regulation prior to and concomitantly with ovarian stimulation. Receiver operating characteristic (ROC) curve analysis was used for statistics. The area under the curve (AUC) provides a measure to show how good (AUC close to 1) or how poor (AUC close to 0.5) a test is. If down-regulation was defined as oestradiol <40, <60 or <80 pg/ml, the AUC of 3D-ultrasound was 0.57, 0.83 and 0.97 respectively. The highest sensitivity (100%) and specificity (93.2%) of 3D-ultrasound was achieved if down-regulation was defined as oestradiol <80 pg/ml (n = 44), with an endometrial volume of 1.9 ml. If down-regulation was defined as oestradiol <60 pg/ml (n = 42) the best combination of highest sensitivity (95.2%) and specificity (75.0%) was obtained with an endometrial volume of 1.9 ml. The comparison of 3D volume calculation with endometrial thickness measurement revealed no significant difference in predicting down-regulation. 3D volume estimation provides a new tool for diagnosing relative hypo-oestrogenism or down-regulation, but it was not superior to two-dimensional ultrasound.

Key words: 3D ultrasound/down-regulation/endometrial volume/hormones/IVF

3 To whom correspondence should be addressed at: Women's General Hospital Linz, Lederergasse 47, A-4020 Linz, Austria.E-mail: yaman{at}aon.at


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T. J. Child, C. Sylvestre, and S. L. Tan
Endometrial volume and thickness measurements predict pituitary suppression and non-suppression during IVF
Hum. Reprod., December 1, 2002; 17(12): 3110 - 3113.
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