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Human Reproduction, Vol. 15, No. 8, 1776-1780, August 2000
© 2000 European Society of Human Reproduction and Embryology

Comparison between day-2 embryos obtained either from ICSI or resulting from short insemination IVF: influence of maternal age*

Yves Ménézo1,3 and Yona Barak2

1 Laboratoire Marcel Merieux, 1 Rue Laborde, 69500 BRON, France and 2 In Vitro Fertilization Unit, Herzliya Medical Center, 7 Ramot-Yam Street, Herzliya-on-Sea 46851, Israel

Short incubation time prevents deleterious effects of cumulus cell degeneration and excess spermatozoa in IVF embryos. We performed a short incubation (3 h) protocol in 328 IVF cycles, in order to compare the developmental potential of regular IVF embryos with those originating from 316 cycles entered our intracytoplasmic sperm injection (ICSI) programme over the same period. Embryo transfers were performed in all patients on day 2. The mean number of embryos transferred was 1.92 for the ICSI group and 1.73 for the IVF group (P < 0.007). This was related only to the wishes of patients. However, the policy of the centre is to transfer a low number of embryos in young patients in order to avoid multiple pregnancies. All spare embryos were permitted to grow to the blastocyst stage for freezing. Shortening incubation time did not decrease fertilization rates. In our overall population, no difference was observed in the implantation rates per embryo for IVF (19%) or for ICSI (20%). An age-related decrease in embryo production was observed for both groups of patients (P < 0.01 for ICSI and P < 0.001 for IVF). The age-related decrease in embryo implantation was only significant for the IVF group (P < 0.03 for patients <30 and >35 years of age). A significant overall decrease in blastocyst formation was observed for spare embryos after ICSI versus IVF (34.2 versus 43.8%; P < 0.05). The significance of this observation is discussed.

Key words: embryo implantation/ICSI/IVF/short insemination time

3 To whom correspondence should be addressed at: Laboratoire Marcel Merieux, 1 Rue Laborde, 69500 Bron France, France.E-mail: yves.menezo{at}insa-lyon.fr

* Presented in part at the 1999 American Society for Reproductive Medicine, September 25–30, 1999, Toronto.


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J. Archer, D. A. Gook, and D. H. Edgar
Blastocyst formation and cell numbers in human frozen-thawed embryos following extended culture
Hum. Reprod., August 1, 2003; 18(8): 1669 - 1673.
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