Human Reproduction, Vol. 15, No. 9, 1958-1961,
September 2000
© 2000 European Society of Human Reproduction and Embryology
Fertility and offspring sex ratio of men who develop testicular cancer: a record linkage study
1 Centre for Research in Health & Social Statistics, Sejrøgade 11, DK-2100, 2 The Sperm Analysis Laboratory, Health Service Physicians Organisation, Pilestræde, Copenhagen, 3 Institute of Cancer Epidemiology, The Danish Cancer Society, Strandboulevarden 49, Box 839, DK-2100, 4 Department of Growth and Reproduction, National University Hospital, Blegdamsvej 9, DK-2100, Denmark and 5 Thames Cancer Registry, Guy's, King's and St Thomas' School of Medicine, 42 Weston Street, London SE1 3QD, UK
Analysis of associations between testicular cancer, subfertility and offspring sex ratio (proportion of males born among newborns) was performed on 3530 Danish men, born 1945–1980, who developed testicular cancer in the period 1960–1993. As the basis of comparison we used the total population of Danish men born in the period 1945–1980 (n = 1 488 957) and their biological children (n = 1 250 989). Men who developed testicular cancer had, prior to the cancer diagnosis, a reduced fertility (standardized fertility rate ratio: 0.93, 95% confidence interval: 0.89–0.97) and a significantly lower proportion of boys (48.9%, P = 0.02) compared with the general population (51.3%). The reduction in fertility was more pronounced in men with non-seminoma but the reduction in offspring sex ratio was independent of histological type. This confirms earlier results from less conclusive studies and indicates that testicular cancer, male subfertility and a female-biased sex ratio among new-born infants are characteristics of male reproduction that are linked by biological mechanisms.
Key words: cohort study/fertility/sex ratio/testicular cancer
6 To whom correspondence should be addressed at: Department of Epidemiology, Institute of Public Health, Faculty of Health Sciences, University of Copenhagen, Panum Institute,Blegdamsvej 3, DK-2200 Copenhagen N, Denmark. Email: R.jacobsen{at}pubhealth.ku.dk
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