Human Reproduction, Vol. 15, No. 9, 2011-2017,
September 2000
© 2000 European Society of Human Reproduction and Embryology
Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions
1 Departments of 1Obstetrics and Gynecology and 2 Microbiology, Faculty of Medicine, Kuwait University, and 3 Maternity Hospital, Kuwait
Concentrations of the T-helper (Th) 1 cytokines interleukin (IL)-2, tumour necrosis factor (TNF) -
, TNF-ß and interferon-
, Th2 cytokines IL-4, IL-5, IL-6, IL-10 as well as those of soluble CD30 in sera have been examined during the three trimesters of gestation, at delivery in normal pregnancy, and at the time of spontaneous abortion in women with a history of unexplained recurrent spontaneous abortion (RSA). Significantly higher concentrations of the Th2 cytokines IL-6 and IL-10 were found at normal delivery than in women with RSA, and conversely significantly increased concentrations of the Th1-type cytokine TNF- were found in RSA as compared with successful pregnancy. In abortion-prone women who had a successful pregnancy, significantly higher concentrations of IL-6 and significantly lower concentrations of TNF- were found as compared with abortion-prone women who had another abortion, supporting the notion that Th2- and Th1-bias are associated with successful and unsuccessful pregnancy respectively. Serum CD30 concentrations did not correlate with the outcome of pregnancy. These findings support observations drawn from experiments on the cytokine secretion profiles of peripheral blood mononuclear cells and decidual lymphocytes which suggest that normal pregnancy is Th2-biased and that unexplained RSA is associated with Th1-type reactivity.
Key words: CD30/pregnancy/recurrent spontaneous abortion/Th1 cytokines/Th2 cytokines
4 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Faculty of Medicine, Kuwait University, PO Box 24923, Kuwait 13110.E-mail: Abrar{at}hsc.kuniv.edu.kw
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