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Human Reproduction, Vol. 15, No. 9, 2023-2027, September 2000
© 2000 European Society of Human Reproduction and Embryology

Pregnancy outcome and infant follow-up of fetuses with abnormally increased first trimester nuchal translucency

Ron Maymon1,3, Eric Jauniaux2, Ofir Cohen1, Eli Dreazen1, Zwi Weinraub1 and Arie Herman1

1 Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, Israel and 2 Academic Department of Obstetrics and Gynaecology, Royal Free and University College, London, UK

The numbers of fetuses with an abnormal increased first trimester nuchal translucency (NT) but a confirmed normal anatomy and karyotyping is relatively small and therefore a challenge for prenatal counselling. The aim of the current study was to assess the long-term pregnancy outcome and infancy prognosis of 78 fetuses with NT > 95th centile of the normal range for crown–rump length (CRL). The most common abnormalities in this group were aneuploidy, which affected 32 of the fetuses followed by four and three cases which were miscarried or had cardiac defects respectively. The remaining euploid fetuses with normal detailed scans were followed throughout their infancy (mean 24 months; range 12–36 months). Post-natally, except for a correctable case of ventricular septal defect and a case of posterior urethral valve, no other abnormalities were detected. After excluding all aneuploid cases and using the maternal age as a second variable, an uncomplicated pregnancy outcome could be anticipated in 17 cases (100%) when the maternal age was <30 years and NT between 95th centile and 5 mm. However, the chance of a normal outcome dropped to 50% in four cases with maternal age >=30 years and NT >=5 mm (Fisher's exact test; P = 0.02). These findings suggest that the long-term prognosis of the euploid fetuses with large NT (<5 mm) is reassuring in younger women.

Key words: fetal karyotype/fetal outcome/neonatal outcome/nuchal translucency/ultrasound

3 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin 70300 (affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv), Israel.E-mail: intposgr{at}post.tau.ac.il


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