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Human Reproduction, Vol. 15, No. suppl_1, pp. 60-73, 2000
© 2000 European Society of Human Reproduction and Embryology

The relative effects of progesterone and progestins in hormone replacement therapy

G.M.C. Rosano1,3, C. Sarais2, S. Zoncu2 and G. Mercuro2

1 Department of Cardiology, H.San Raffaele Roma-EUR Via Elio Chianesi 33, 00144 Rome, Italy 2 Institute of Cardiology, University of Cagliari 09124 Cagliari, Italy

Correspondence: 3To whom correspondence should be addressed

Hormone replacement therapy (HRT) was initially given to protect women against osteoporosis and alleviate menopausal symptoms, such as hot flashes, depression, sleep disturbances, and vaginal dryness. In view of the understanding of oestrogen deficiency as a major trigger for the acceleration of cardiovascular risk after menopause, HRT may also be proposed as a substantial beneficial cardioprotective agent. Progestins, which may be added to oestrogen in combined HRT to reduce the risk of uterine malignancy, have a number of potential adverse effects on the cardiovascular system which could even attenuate the benefit of unopposed oestrogen replacement therapy in post-menopausal women.

Key words: cardiovascular system/coronary artery disease/hormone replacement therapy


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