Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Rodríguez-Manzaneque, J. C.
Right arrow Articles by Iruela-Arispe, M.L.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Rodríguez-Manzaneque, J. C.
Right arrow Articles by Iruela-Arispe, M.L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 15, No. suppl_3, pp. 39-47, 2000
© 2000 European Society of Human Reproduction and Embryology

Endothelial cell dysfunction following prolonged activation of progesterone receptor

Juan Carlos Rodríguez-Manzaneque, Michael Graubert and M.Luisa Iruela-Arispe1

Department of Molecular, Cell and Developmental Biology, and Molecular Biology Institute, University of California Los Angeles, CA 90095, USA

Correspondence: 1To whom correspondence should be addressed at: Molecular Biology Institute, 611 Charles Young Drive, Los Angeles, CA 90095, USA. E-mail: arispe{at}mbi.ucla.edu

Progestin-only contraceptives are associated with breakthrough bleeding in up to 50% of users. The causes of blood vessel rupture are not well understood. Here we report that both normal and Norplant®-exposed endothelium express progesterone receptor. Experiments performed in vitroon endothelial cells isolated from human endometrium revealed that longterm progesterone exposure leads to suppression of endothelial cell proliferation, inhibition of migration and alteration in the profile of extracellular matrix proteins secreted by human endometrial endothelial cells. In addition, we detected increased levels of matrix metalloproteinase-9 in endothelialcultures treated with progesterone. The effect of progesterone on the cell cycle, along with the increased amounts of matrix-degrading enzymes, could account for breakdown of basement membrane components, vascular fragility and consequent vessel rupture leading to breakthrough endometrial bleeding.

Key words: angiogenesis/endothelial cell/migration/progesterone/proliferation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
M. S. M. van Mourik, N. S. Macklon, and C. J. Heijnen
Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment
J. Leukoc. Biol., January 1, 2009; 85(1): 4 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P.G.L. Lalitkumar, S. Lalitkumar, C.X. Meng, A. Stavreus-Evers, F. Hambiliki, U. Bentin-Ley, and K. Gemzell-Danielsson
Mifepristone, but not levonorgestrel, inhibits human blastocyst attachment to an in vitro endometrial three-dimensional cell culture model
Hum. Reprod., November 1, 2007; 22(11): 3031 - 3037.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
J. Fahnenstich, A. Nandy, K. Milde-Langosch, T. Schneider-Merck, N. Walther, and B. Gellersen
Promyelocytic leukaemia zinc finger protein (PLZF) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells
Mol. Hum. Reprod., October 1, 2003; 9(10): 611 - 623.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Creus, J. Ordi, F. Fabregues, R. Casamitjana, F. Carmona, A. Cardesa, J. A. Vanrell, and J. Balasch
The effect of different hormone therapies on integrin expression and pinopode formation in the human endometrium: a controlled study
Hum. Reprod., April 1, 2003; 18(4): 683 - 693.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. Kosaka, H. Fujiwara, K. Tatsumi, S. Yoshioka, T. Higuchi, Y. Sato, T. Nakayama, and S. Fujii
Human peripheral blood mononuclear cells enhance cell-cell interaction between human endometrial epithelial cells and BeWo-cell spheroids
Hum. Reprod., January 1, 2003; 18(1): 19 - 25.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.