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Human Reproduction, Vol. 16, No. 10, 2109-2113, October 2001
© 2001 European Society of Human Reproduction and Embryology

The outcome of intracytoplasmic injection of fresh and cryopreserved ejaculated spermatozoa—a prospective randomized study

W. Kuczynski1,2,5, M. Dhont3, C. Grygoruk1,2, D. Grochowski4, S. Wolczynski4 and M. Szamatowicz1

1 Department of Gynecology, Institute of Obstetrics and Gynecology, 2 Cryobank—Infertility Center, Bialystok, Poland, 3 Infertility Center, Department of Obstetrics and Gynecology, Ghent University Hospital, Belgium and 4 Department of Gynecological Endocrinology, Institute of Obstetrics and Gynecology, Bialystok, Poland

BACKGROUND: The overall aim of this prospective, randomized study was to compare the reproductive potential of fresh and frozen–thawed ejaculated spermatozoa from oligoasthenoteratozoospermic patients in an intracytoplasmic sperm injection (ICSI) procedure. METHODS: All patients consenting to participate in this study had a sperm sample frozen prior to the start of a cycle. Patients were randomized using a random number table to undergo ICSI with either fresh (group A, n = 118) or frozen–thawed (group B, n = 122) spermatozoa. All prognostic variables were equally distributed among the two groups. RESULTS: The pregnancy rate per started cycle was 29.7% in group A and 38.5% in group B, P > 0.05. A significant difference was observed in the rate of ongoing pregnancies between group A (23.7%) and group B (35.2%), P < 0.05. CONCLUSION: From our data we can conclude that cryopreservation of spermatozoa from men with poor sperm quality does not negatively affect fertilization and pregnancy rates after ICSI. A larger study will be needed to investigate whether the use of cryopreserved spermatozoa can be helpful in selecting the most vital spermatozoa for ICSI.

Key words: sperm cryopreservation/ICSI/fertilization/pregnancy/prospective randomized study

5 To whom correspondence should be addressed at: Department of Gynecology, Bialystok Medical University, Sklodowskiej 24 A, Bilystok 15-276, Poland. E-mail: kuczynsk{at}cksr.ac.bialystok.pl


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