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Human Reproduction, Vol. 16, No. 10, 2136-2138, October 2001
© 2001 European Society of Human Reproduction and Embryology

An idiopathic infertility with oocytes metaphase I maturation block

Case report

Marianne Bergère1,3, Raoul Lombroso2, Myriam Gombault1, Robert Wainer2 and Jacqueline Selva1

1 Departments of Reproductive Biology and Cytogenetics and 2 Gynecology and Obstetrics, CHI Poissy Saint Germain, 78303 Poissy, Paris-Ouest University, France

BACKGROUND: A case of idiopathic primary infertility was attributed to a block in oocyte meiosis affecting the transition between metaphase I and metaphase II. METHODS AND RESULTS: A couple suffering unexplained primary infertility was unsuccessfully treated by various means of assisted reproductive technology. After four unsuccessful pregnancy attempts using intrauterine inseminations (IUI), IVF was attempted (all oocytes remained unfertilized), followed by an ICSI cycle. None of the retrieved oocytes expelled the polar body, and therefore were not injected. The failure of these assisted reproduction cycles was, in both cases, due to the immaturity of the oocytes recovered. Cytogenetic analysis of the oocytes retrieved for ICSI provided evidence of meiotic arrest. Using cytogenetic staging criteria we were able to show that this arrest occurred between metaphase I and anaphase I. CONCLUSIONS: Meiotic blocks affecting oocytes have already been described for various mammals. We discuss here mechanisms that might be involved in this possibly inherited disorder in humans, and ways in which our knowledge of them could be increased.

Key words: ICSI/meiosis block/metaphase I/oocytes

3 To whom correspondence should be addressed. E-mail:mabpoissy{at}hotmail.com


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