Human Reproduction, Vol. 16, No. 10, 2219-2226,
October 2001
© 2001 European Society of Human Reproduction and Embryology
Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions
1 Departments of Obstetrics & Gynecology and 2 Microbiology, Faculty of Medicine, Kuwait University and 3 Maternity Hospital, Kuwait
BACKGROUND: This study compared Th1–Th2 cytokine profiles in a subgroup of recurrent aborters who had an abortion with those in a subgroup of recurrent aborters who had a successful pregnancy. METHODS: Fifty-four women with a history of at least three normal pregnancies, 24 women with a history of recurrent spontaneous abortion (RSA) followed by abortion (RSA
A) and 39 women with a history of RSA followed by normal pregnancy (RSAN) were studied. Blood samples and placentas were obtained at the time of delivery or abortion; peripheral blood mononuclear cells were stimulated separately with phytohaemagglutinin and with autologous placental cells, and the secreted cytokines estimated. RESULTS: Peripheral blood mononuclear cells from the RSAN subgroup secreted higher concentrations of Th1-type cytokines as compared with normal pregnant women, indicating a higher Th1 bias in these women. However, women in the RSAN subgroup had significantly higher concentrations of Th2 cytokines as compared with women in the RSAA subgroup. A comparison of Th1:Th2 cytokine ratios indicated a higher Th2 bias in RSAN women as compared with RSAA women. CONCLUSIONS: We conclude that abortion-prone women who proceed to have successful pregnancy are more Th2-biased than abortion-prone women who abort, and that recurrent aborters who undergo spontaneous abortion have a stronger Th1 bias than aborters who have normal pregnancy.
Key words: pregnancy/recurrent spontaneous abortion/Th1 cytokines/Th2 cytokines
4 To whom correspondence should be addressed at: Department of Obstetrics & Gynecology, Faculty of Medicine, Kuwait University, P.O.Box 24923, Kuwait 13110.
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