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Human Reproduction, Vol. 16, No. 11, 2283-2287, November 2001
© 2001 European Society of Human Reproduction and Embryology

Incomplete miscarriage: a randomized controlled trial comparing oral with vaginal misoprostol for medical evacuation

M.W. Pang,1, T.S. Lee and T.K.H. Chung

Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR

BACKGROUND: A prospective randomized controlled trial was conducted to compare the efficacy and side-effects of vaginal versus oral misoprostol in the medical management of incomplete miscarriage. METHODS: Two hundred and one patients who miscarried consented to randomization using computer-generated randomization model prior to treatment. A total of 800 µg of misoprostol was given either vaginally or orally to the randomized subjects. A second dose was repeated 4 h later if the product of conception had not been passed. RESULTS: The incidence of complete uterine evacuation following vaginal and oral misoprostol was similar [(58/95) 61.1% versus (67/103) 64.4%]. There was a significantly decreased incidence of diarrhoea [(12/95) 13.6% versus (62/103) 65.3%, P < 0.01] with the use of vaginal misoprostol. CONCLUSIONS: Vaginal misoprostol was as effective as oral misoprostol in medical uterine evacuation in patients with incomplete miscarriage. There was also a reduction in the incidence of diarrhoea with the use of vaginal misoprostol.

Key words: incomplete miscarriage/misoprostol/side-effects/vaginal

1 To whom correspondence should be addressed: E-mail: mwpang{at}cuhk.edu.hk


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