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Human Reproduction, Vol. 16, No. 11, 2305-2309, November 2001
© 2001 European Society of Human Reproduction and Embryology

Clomiphene citrate does not affect the secretion of {alpha}3, {alpha}V and ß1 integrin molecules during the implantation window in patients with unexplained infertility

S. Lacin1,3, S. Vatansever2, N.K. Kuscu1, F. Koyuncu1, K. Ozbilgin2 and E. Ceylan1

1 Department of Obstetrics and Gynaecology and 2 Department of Histology and Embryology, School of Medicine, Celal Bayar University, Manisa, Turkey

BACKGROUND: The expression of integrin molecules on the endometrium suggests that certain integrins may participate in the cascade of molecular events leading to successful implantation. A prospective, controlled study was carried out to investigate the effect of clomiphene citrate (CC) on secretions of ß1, {alpha}3 and {alpha}V integrin molecules in the endometrium of patients with unexplained infertility during the implantation window. METHODS: A total of 40 endometrial samples was evaluated in both spontaneous (n = 13) and ensuing clomiphene-treated cycles (100 mg on days 5–9) and also from fertile women serving as controls (n = 14) during postovulatory 7th or 8th day of menstrual cycle. A semiquantitative grading system (H-score) was used to compare the immunohistochemical staining intensities. Endometrial thickness and serum oestradiol and progesterone concentrations were also measured on the day of sampling. RESULTS: Staining of {alpha}v but not ß1 and {alpha}3 integrins was significantly less intense in infertile cases than fertile control cases (1.42 ± 0.12 versus 2.21 ± 0.13 respectively, P = 0.012) and this was not restored to normal concentrations with treatment. CONCLUSIONS: Our study indicated that cc treatment significantly decreased the endometrial thickness and increased oestradiol and progesterone concentrations. However, secretion of {alpha}v, ß1 and {alpha}3 integrin molecules, which might play a role in implantation, was not affected.

Key words: clomiphene/implantation/integrins/unexplained infertility

3 To whom correspondence should be addressed at: Sakarya Mahallesi Uzunyol Caddesi, No: 122/2 Unlu-II Apt., 45020 Manisa, Turkey. E-mail: lacins{at}egenet.com.tr


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