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Human Reproduction, Vol. 16, No. 11, 2347-2349, November 2001
© 2001 European Society of Human Reproduction and Embryology

Pregnancy achieved following ICSI from a man with Klinefelter's syndrome and spinal cord injury

Case report

Koichi Kyono1,3, Noritaka Fukunaga1, Kosuke Haigo1, Setsuyo Chiba1 and Yasuhisa Araki2

1 Ladies Clinic Kyono, Furukawa, Miyagi and 2 Institute for ARMT, Seta-gun, Gunma, Japan

Klinefelter's syndrome and spinal cord injury are major causes of male infertility. Intracytoplasmic sperm injection (ICSI) is a relatively new method of assisted reproduction. A testicular biopsy was obtained from a patient with the double complications of non-mosaic 47,XXY Klinefelter's syndrome and spinal cord damage, and motile spermatozoa were collected. ICSI was then performed. Of the four sperm-injected oocytes, three became fertilized and cleaved. Two embryos were implanted, resulting in a single pregnancy with visible evidence of a heartbeat appearing at 6 weeks gestation. The pregnancy is now entering its 20th week. To the best of our knowledge, this is the first case of a pregnancy resulting from the sperm of a patient with double complications.

Key words: azoospermia/Klinefelter's syndrome/spinal cord injury/testicular biopsy

3 To whom correspondence should be addressed at: Ladies Clinic Kyono, 3-8-6 Oomiya, Furukawa, Miyagi 989-6221, Japan.E-mail: a1951414{at}coral.ocn.ne.jp


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