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Human Reproduction, Vol. 16, No. 11, 2434-2437, November 2001
© 2001 European Society of Human Reproduction and Embryology

Are serum inhibin concentrations new markers of placental tumours in the course of chemotherapy?

P. Pautier1,5, S. Ghione2, S. Brailly-Tabard4, C. Lhommé3, P. Morice3 and J.M. Bidart2

1 Medical Department, Gynecological Unit, 2 Clinical Biological Department and 3 Surgical Department, Institut Gustave-Roussy, 94805 Villejuif and 4 Molecular Biology and Hormonology Department, Hôpital Bicêtre, 94275 Le Kremlin-Bicêtre Cedex, France

BACKGROUND: The study was conducted to evaluate whether the detection of serum molecular forms of inhibin (A and B) could be useful for the diagnosis, prognosis and follow-up of placental tumours. METHODS: A total of 17 patients with hydatidiform mole (n = 13), invasive mole (n = 1) or choriocarcinoma (n = 3) were studied; serum concentrations of inhibins A and B, human chorionic gonadotrophin (HCG) and its free ß subunit (HCGß) were measured before chemotherapy (after mole evacuation for eight patients) and also during the course of chemotherapy (for 10 patients). RESULTS: After evacuation or before chemotherapy for refractory disease, serum inhibin A and B concentrations were found to be increased in 10/17 and 4/17 patients, when HCG and HCGß were high in all patients. In 10 patients with a follow-up during treatment, nine had a high concentration of inhibin A which correlated with those of HCG and HCGß. Normalization of inhibin A was faster than that of HCG and HCGß for three and six patients respectively. There was no correlation between changes of inhibin B and HCGß concentrations. CONCLUSIONS: Our results suggest that inhibins A and B are not useful markers and that HCG determination still remains the most useful marker for diagnosis and follow-up of placental tumours.

Key words: human chorionic gonadotrophin/inhibin/marker/trophoblastic disease

5 To whom correspondence should be addressed. E-mail: pautier{at}igr.fr


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