Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (34)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Bos-Mikich, A.
Right arrow Articles by Ferrari, A.N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bos-Mikich, A.
Right arrow Articles by Ferrari, A.N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 16, No. 12, 2658-2661, December 2001
© 2001 European Society of Human Reproduction and Embryology

Early cleavage of human embryos: an effective method for predicting successful IVF/ICSI outcome

A. Bos-Mikich,1, A.L.G. Mattos and A.N. Ferrari

Fundaçao Universitária de Endocrinologia e Fertilidade (FUEFE), Rua Alcides Cruz 101, CEP: 90.630–160, Porto Alegre, RS, Brazil

BACKGROUND: The need for effective parameters for selecting the best embryos is paramount when a large number of them are available for transfer. Other studies have reported that transfer of pre-selected embryos, based on cleavage to the 2-cell stage at 25 h and 27 h post-insemination/intracytoplasmic sperm injection (ICSI), increases implantation and pregnancy rates. We investigated whether extending the time for selection of cleaved embryos to 29 h post-insemination/ICSI had a similar effect on pregnancy and implantation rates. METHODS: Cleavage to the 2-cell stage was assessed at 25, 27 and 29 h post-insemination/ICSI. Embryos that had cleaved at any of these time points were designated as `early cleavage' (EC), while others were designated as `non-early cleavage' (NEC). EC embryos were selected and preferentially transferred. RESULTS: EC occurred in 57% of the cycles (61% IVF; 51% ICSI). Significantly (P = 0.02) more clinical pregnancies occurred in the EC group (23/42, 55%) compared with the group that had no embryo undergoing first cleavage up to 29 h post-insemination/ICSI (8/32, 25%). The EC group of patients was significantly younger than the NEC. CONCLUSION: Transfer of selected embryos that reached the 2-cell stage between 25 and 29 h post-insemination/ICSI is a reliable prognostic tool for patients undergoing assisted reproduction techniques.

Key words: assessment times/early cleavage/embryo selection/pregnancy rates

1 To whom correspondence should be addressed. E-mail: adriana{at}orion.ufrgs.br


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
J. M.R. Gerris
Single embryo transfer and IVF/ICSI outcome: a balanced appraisal
Hum. Reprod. Update, March 1, 2005; 11(2): 105 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. P.A. Van Montfoort, J. C.M. Dumoulin, A. D.M. Kester, and J. L.H. Evers
Early cleavage is a valuable addition to existing embryo selection parameters: a study using single embryo transfers
Hum. Reprod., September 1, 2004; 19(9): 2103 - 2108.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M.-L. Windt, T.F. Kruger, K. Coetzee, and C.J. Lombard
Comparative analysis of pregnancy rates after the transfer of early dividing embryos versus slower dividing embryos
Hum. Reprod., May 1, 2004; 19(5): 1155 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L. R. Fraser and O. O. Osiguwa
Human sperm responses to calcitonin, angiotensin II and fertilization-promoting peptide in prepared semen samples from normal donors and infertility patients
Hum. Reprod., March 1, 2004; 19(3): 596 - 606.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
V. Soderstrom-Anttila, S. Vilska, S. Makinen, T. Foudila, and A.-M. Suikkari
Elective single embryo transfer yields good delivery rates in oocyte donation
Hum. Reprod., September 1, 2003; 18(9): 1858 - 1863.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.