Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (24)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by van Golde, R. J.T.
Right arrow Articles by Kremer, J. A.M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Golde, R. J.T.
Right arrow Articles by Kremer, J. A.M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 16, No. 2, 289-292, February 2001
© 2001 European Society of Human Reproduction and Embryology

Decreased fertilization rate and embryo quality after ICSI in oligozoospermic men with microdeletions in the azoospermia factor c region of the Y chromosome

Ron J.T. van Golde1, Alex M.M. Wetzels1, Ruurd de Graaf3, Joep H.A.M. Tuerlings2, Didi D.M. Braat1 and Jan A.M. Kremer1,4

1 Departments of Obstetrics and Gynaecology, 2 Human Genetics and 3 Epidemiology and Biostatistics, University Medical Centre Nijmegen, Nijmegen, The Netherlands

Microdeletions of the azoospermia factor (AZF) region of the Y chromosome occur in between 1 and 29% of oligozoospermic and azoospermic men, and most deletions are found in the AZFc region. These men can father children when intracytoplasmic sperm injection (ICSI) is used, but the success rate is unclear. Thus, the success rate of 19 ICSI treatments in eight couples with a microdeletion in the AZFc region of the Y chromosome was analysed retrospectively. These were compared with a control group of 239 ICSI treatments in 107 couples undergoing ICSI treatment with ejaculated spermatozoa. The fertilization rate was significantly lower in the group of Y-deleted men (55%; 95% CI: 41–69%) compared with controls (71%; 95% CI: 67–74%; P < 0.01). The embryo quality was also significantly poorer among Y-deleted men (P < 0.001). Pregnancy, implantation and take-home baby rates were not significantly lower in the Y-deleted group. This study shows that ICSI in oligozoospermic men with microdeletions in the AZFc region of the Y chromosome leads to a lower fertilization rate and poorer embryo quality.

Key words: assisted reproduction outcome/ICSI/male infertility/microdeletions

To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, University Medical Centre Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail: j.kremer{at}obgyn.azn.nl


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
J.D.M. Nicopoullos, C. Gilling-Smith, P.A. Almeida, S. Homa, L. Nice, H. Tempest, and J.W.A. Ramsay
The role of sperm aneuploidy as a predictor of the success of intracytoplasmic sperm injection?
Hum. Reprod., February 1, 2008; 23(2): 240 - 250.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
B. Wu, N.X. Lu, Y.K. Xia, A.H. Gu, C.C. Lu, W. Wang, L. Song, S.L. Wang, H.B. Shen, and X.R. Wang
A frequent Y chromosome b2/b3 subdeletion shows strong association with male infertility in Han-Chinese population
Hum. Reprod., April 1, 2007; 22(4): 1107 - 1113.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
E. Seli and D. Sakkas
Spermatozoal nuclear determinants of reproductive outcome: implications for ART
Hum. Reprod. Update, July 1, 2005; 11(4): 337 - 349.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. Stouffs, W. Lissens, H. Tournaye, A. Van Steirteghem, and I. Liebaers
The choice and outcome of the fertility treatment of 38 couples in whom the male partner has a Yq microdeletion
Hum. Reprod., July 1, 2005; 20(7): 1887 - 1896.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
I. E. Aknin-Seifer, H. Lejeune, R. L. Touraine, R. Levy, and Under the aegis of the SALF (Societe d'Andrologie
Y chromosome microdeletion screening in infertile men in France:a survey of French practice based on 88 IVF centres
Hum. Reprod., April 1, 2004; 19(4): 788 - 793.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J.Y.M. Tse, E.Y.M. Wong, A.N.Y. Cheung, W.S. O, P.C. Tam, and W.S.B. Yeung
Specific Expression of VCY2 in Human Male Germ Cells and Its Involvement in the Pathogenesis of Male Infertility
Biol Reprod, September 1, 2003; 69(3): 746 - 751.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. D. Oates, S. Silber, L. G. Brown, and D. C. Page
Clinical characterization of 42 oligospermic or azoospermic men with microdeletion of the AZFc region of the Y chromosome, and of 18 children conceived via ICSI
Hum. Reprod., November 1, 2002; 17(11): 2813 - 2824.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
B. Peterlin, T. Kunej, J. Sinkovec, N. Gligorievska, and B. Zorn
Screening for Y chromosome microdeletions in 226 Slovenian subfertile men
Hum. Reprod., January 1, 2002; 17(1): 17 - 24.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.