Human Reproduction, Vol. 16, No. 4, 790-800,
April 2001
© 2001 European Society of Human Reproduction and Embryology
Prevention of twin pregnancies after IVF/ICSI by single embryo transfer*
Twin pregnancies constitute the most serious complication for both mother and children after IVF/ICSI treatment, but transfer of at least two `best looking' embryos remains the standard policy. This is due to our inability and reluctance to identify both the `twin prone' patient and the top quality embryo. Some centres now electively transfer a single embryo (eSET) when particular embryo quality and patient criteria are met. Results from several centres were presented during an ESHRE Campus Course, held on May 6th 2000. Sound clinical trials are needed to clarify several points of discussion. What is the clinical profile of patients in whom eSET should be considered? Will the overall (ongoing) pregnancy rate of the IVF/ICSI programme decrease if eSET is performed in these patients? What is the twinning rate when eSET is a routine policy? Will the financial gain by avoiding perinatal hospitalization costs of prevented twins be balanced by the likely need to perform a number of extra IVF/ICSI cycles? What will be gained by freezing the extra number of high quality embryos? Should eSET be performed at the 2 pronuclear stage, the early cleaving embryo or the blastocyst stage? Common sense dictates that eSET as a concept should be applied from now onwards.
Key words: elective single embryo transfer (eSET)/ICSI/IVF/prevention/twin pregnancies
To whom correspondence should be addressed: J.Gerris, Center for Reproductive Medicine, Middelheim Hospital, Lindendreef 1, 2020, Antwerp, Belgium. E-mail: jan.gerris{at}ocmw.antwerpen.be
* An ESHRE Campus Course was organized on May 6th 2000 in Antwerp, Belgium with an educational grant from Serono Symposia and the Marguérite-Marie Delacroix Foundation for the prevention of cerebral palsy. The speakers included: T.Coetsier (Ghent), P.Devroey (Brussels), M.Dhont (Ghent), R.G.Edwards (Cambridge), H.Evers (Maastricht), L.Hägglund (Malmö), A.Handyside (Leeds), J.Gerris (Antwerp), J.Koudstaal (Utrecht), S.Vilska (Helsinki), J.Tapanainen (Oulu), J.van Blerkom (Boulder, Colorado), P.van Dop (Eindhoven) and E.Van Royen (Antwerp).
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