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Human Reproduction, Vol. 16, No. 6, 1278-1285, June 2001
© 2001 European Society of Human Reproduction and Embryology

High anti-paternal cytotoxic T-lymphocyte precursor frequencies in women with unexplained recurrent spontaneous abortions

Beatrix Kotlan1,5, Vilmos Fülöp2, Ágnes Padányi1, Iván Szigetvári2, Marienn Réti3, Éva Gyódi1, Éva Fehér4 and Gyözö Petrányi1

1 Department Immunogenetics, National Institute of Haematology and Immunology, Budapest, H-1113, 2 Department OB/GYN, Semmelweis University, Faculty of Health Sciences, Budapest, H-1135, 3 Department Haemapheresis, St Laszlo Hospital, Budapest, H-1097, and 4 Department Haemapheresis, National Blood Service, Budapest, H-1113, Hungary

A number of cases of unexplained (idiopathic) recurrent spontaneous abortions may be attributable to immunological mechanisms. Several lines of evidence indicate that some immunocompetent effector cell populations play an important role in the pathogenesis of unexplained miscarriages. However a suitable method is lacking for defining an existing immunological background of recurrent spontaneous abortions. We tried to find a useful cellular immunological method, that is suitable for predicting the eventual immunological cause in the case of unexplained recurrent spontaneous abortions. We have examined the anti-paternal cytotoxic T-lymphocyte precursor frequencies by cell-mediated lympholysis and limiting dilution analysis in the peripheral blood of women with recurrent spontaneous abortions in order to reveal the functional role of this cell population in spontaneous abortions. An extremely high partner allo-antigen-specific cytotoxic T-lymphocyte precursor frequency was determined in the case of all those habitual aborters, where no other than an immunological cause could be responsible for the abortions. This phenomenon supports the important role of the T-lymphocytes in this disorder. We suggest that the immunological background of recurrent spontaneous miscarriages might be determined on the basis of a very high cytotoxic T-lymphocyte precursor frequency. This diagnostic test might be useful in selecting patients for immunotherapy.

Key words: cytotoxic T-lymphocyte precursors/immunological background/recurrent spontaneous abortion

5 To whom correspondence should be addressed. E-mail: b.kotlan{at}ohvi.hu


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