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Human Reproduction, Vol. 16, No. 7, 1424-1426, July 2001
© 2001 European Society of Human Reproduction and Embryology

Ongoing twin pregnancy after ICSI of PESA-retrieved spermatozoa into in-vitro matured oocytes: Case report

Ahmad Kamal Abdul-Jalil1,3, Tim J. Child1, Simon Phillips1, Nicola Dean1, Serge Carrier2 and Seang Lin Tan1

1 McGill Reproductive Center, Department of Obstetrics and Gynecology and 2 Department of Surgery, McGill University, Montreal, Quebec, Canada

The recovery of immature oocytes from unstimulated ovaries followed by in-vitro maturation (IVM) is an attractive alternative to conventional IVF in the treatment of female infertility. Similarly, surgical recovery of spermatozoa from the epididymis by percutaneous sperm aspiration (PESA) has simplified the retrieval of the male gamete in treatment of men with obstructive azoospermia. We report the first ongoing clinical twin pregnancy resulting from intracytoplasmic sperm injection (ICSI) of spermatozoa retrieved by PESA into IVM oocytes. In the treatment of a 24-year old woman, 12 immature oocytes were retrieved. Six oocytes matured (maturation rate 50%) after 24-hour incubation and were inseminated by ICSI. Four oocytes had two pronuclei (fertilization rate 67%) and 3 good quality embryos were transferred. A viable twin pregnancy was confirmed by ultrasound scan. This report illustrates the use of a combination of less invasive assisted reproductive techniques in overcoming barriers to infertility.

Key words: In-vitro maturation/human oocytes/polycystic ovaries/percutaneous sperm aspiration

3 To whom correspondence should be addressed at: McGill Reproductive Center, Royal Victoria Hospital F6.58, 687 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada. E-mail: ahmad.kamal{at}muhc.mcgill.ca


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