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Human Reproduction, Vol. 16, No. 7, 1486-1488, July 2001
© 2001 European Society of Human Reproduction and Embryology

The use of misoprostol prior to hysteroscopy in postmenopausal women

S.W. Ngai,1, Y.M. Chan and P.C. Ho

Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China

BACKGROUND: This study examined whether oral misoprostol exerted a cervical priming effect in postmenopausal women prior to hysteroscopy. METHOD: Thirty-seven patients were randomized to receive either oral misoprostol (400 µg) or placebo (vitamin B6) 12 h prior to hysteroscopy. The resistance of the cervix to dilatation was objectively assessed by a cervical tonometer. RESULTS: The mean baseline cervical dilatation (4.2 mm in misoprostol group versus 4.4 mm in placebo group) was similar between the two groups. The mean cumulative force measured (27.7 N in misoprostol group versus 21.8 N in placebo group) was also comparable. None of the patients suffered from any significant side-effects. CONCLUSIONS: These data showed that there were no significant benefits from giving misoprostol pre-operatively in postmenopausal women, and it was concluded that oral misoprostol had no significant cervical priming effect in postmenopausal women.

Key words: cervical priming/misoprostol/oestrogen/postmenopausal women

1 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Tsan Yuk Hospital, Hong Kong SAR, China. E-mail: cora{at}hkucc.hku.hk


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A.M. Darwish, A.M. Ahmad, and A.M. Mohammad
Cervical priming prior to operative hysteroscopy: a randomized comparison of laminaria versus misoprostol
Hum. Reprod., October 1, 2004; 19(10): 2391 - 2394.
[Abstract] [Full Text] [PDF]


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