Human Reproduction, Vol. 16, No. 8, 1619-1624,
August 2001
© 2001 European Society of Human Reproduction and Embryology
Prediction of the potentially fertile period by urinary hormone measurements using a new home-use monitor: comparison with laboratory hormone analyses
1 Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-Ku, Tokyo 160-8582, Japan, 2 Unipath Ltd, Priory Business Park, Bedford, UK and 3 Mitsui Pharmaceuticals Inc., 12–2, Nihonbashi 3-Chome, Chuo-Ku, Tokyo 103-0027, Japan
BACKGROUND: The study compared a new urinary hormone monitoring system, Clearview Primera Fertility Monitor® (CPFM), with laboratory hormone analyses in the prediction of the potentially fertile period. METHODS: Thirty healthy female volunteers provided blood and early morning urine samples for one cycle. Serum oestradiol, progesterone and luteinizing hormone (LH), and urinary LH and oestrone-3-glucuronide (E3G) were measured. The fertility status of volunteers; Low, High or Peak, was collected from monitors and compared with the hormone measurements. RESULTS: There was agreement between the first day of peak fertility and the urinary LH peak day in 65.6% of cycles and detection 1 or 2 days before the urinary LH peak day in 24.1 and 6.9% of cycles respectively. In 58.6% of cycles the system detected up to 5 days of increased fertility prior to the urinary LH peak day. Warning days of the urinary LH peak were similarly determined using defined thresholds of E3G and oestradiol providing up to 5 days warning in 82.8 and 96.6% of cycles respectively. CONCLUSIONS: The system can provide couples attempting to conceive with information about the potentially fertile days in the cycle in order that they may time intercourse. It also has potential for use in evaluation and treatment of infertile couples.
Key words: fertile period/LH/LH surge/oestradiol/urinary metabolite
4 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Tokyo Dental College Ichikawa General Hospital, 11–13, Suagno 5-Chome, Ichikawa-City, Chiba 272–8513, Japan. E-mail: ktanabe{at}tdc.ac.jp
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