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Human Reproduction, Vol. 16, No. 8, 1648-1652, August 2001
© 2001 European Society of Human Reproduction and Embryology

Low-level sex chromosome mosaicism in female partners of couples undergoing ICSI therapy does not significantly affect treatment outcome

B. Sonntag1, D. Meschede2, V. Ullmann1, P. Gassner3, J. Horst2, E. Nieschlag3 and H.M. Behre1,4

1 Assisted Reproduction Unit of the Department of Obstetrics and Gynaecology and the 3 Institute of Reproductive Medicine of the University, and 2 Institute of Human Genetics of the University, Münster, Germany

BACKGROUND: There is an increased rate of chromosomal anomalies, in particular low-level sex chromosome mosaicism, in the female partners of couples undergoing intracytoplasmic sperm injection (ICSI). METHODS: Among 811 consecutive couples presenting for pre-ICSI chromosome analysis, chromosomal abnormalities were detected in 54 individuals, of which 26 were low-level sex chromosome mosaicism in the females. Attention was focused on the treatment course and outcome of ICSI in 20 couples with low-level sex chromosome mosaicism in the females actually embarking on ICSI treatment (group I, n = 38 ICSI treatment cycles). Applying a case–control design, each of the 20 couples was matched according to female age and source of spermatozoa to couples without a chromosomal abnormality in either of the partners (group II, n = 38 ICSI treatment cycles). RESULTS: No significant differences were found between the groups in ovarian response, fertilization rate and number of embryos transferred. Pregnancy rates, as well as implantation and abortion rates did not differ significantly between the groups. CONCLUSIONS: The data suggest that low-level sex chromosome mosaicism in females has no major effect on the course and outcome of ICSI.

Key words: assisted reproduction/ICSI outcome/infertility/sex chromosome mosaicism

4 To whom correspondence should be addressed at: Andrology Unit, Martin-Luther-University, Magdeburger Str. 16, D-06097 Halle, Germany. E-mail: Hermann.Behre{at}medizin.uni-halle.de


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