Human Reproduction, Vol. 16, No. 8, 1732-1735,
August 2001
© 2001 European Society of Human Reproduction and Embryology
Prevention of postoperative adhesion formation in rat uterine horn model by nimesulide: a selective COX-2 inhibitor
1 Departments of Obstetrics and Gynecology and 2 Pharmacology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey
BACKGROUND: Pelvic surgery is one of the main causes of intraperitoneal (i.p.) adhesions that create various medical problems including pelvic pain, bowel obstructions and female infertility. A rat model was used to investigate the efficacy of nimesulide, a selective cyclooxygenase-2 inhibitor, in the prevention of adhesion formation. METHODS: Fifty Wistar-Albino rats underwent bilateral uterine horn injury with a unipolar cautery. Study groups were as follows: (i) control group, no adjuvant therapy; (ii) i.p. Ringer's lactate group, 2 ml Ringer's lactate solution was instilled i.p.; (iii) i.p. Ringer's lactate plus nimesulide group, 1 ml Ringer's lactate plus 1 ml nimesulide (0.5 mg/ml) were given i.p.; (iv) intramuscular (i.m.) nimesulide group, 1 ml i.m. nimesulide (0.5 mg/ml) was given preoperatively for 5 days; and (v) i.p. nimesulide group, 1 ml nimesulide (0.5 mg/ml) was instilled i.p. At the end of the study all animals were killed, and a standard adhesion scoring system was applied by a blinded examiner. RESULTS: The mean adhesion extent in study groups was as follows: 1.33 ± 0.76 in control group, 1.40 ± 0.90 in i.p. Ringer's lactate group, 0.75 ± 0.70 in i.p. Ringer's lactate plus nimesulide group, 0.25 ± 0.44 in i.m. nimesulide group and 0.31 ± 0.70 in i.p. nimesulide group. The mean ± SD adhesion severities of control, i.p. Ringer's lactate, i.p. Ringer's lactate plus nimesulide, i.m. nimesulide, and i.p. nimesulide groups were 0.58 ± 0.35, 0.30 ± 0.41, 0.27 ± 0.3, 0.12 ± 0.28 and 0.15 ± 0.35 respectively. The lowest adhesions were found in the groups treated with nimesulide i.m. and nimesulide i.p. ( P < 0.05). CONCLUSIONS: This study showed that preoperative i.m. or postoperative i.p. administration of nimesulide to the site of injury reduced the formation of postoperative adhesions in a rat uterine horn model.
Key words: adhesion / nimesulide / postoperative / rat / surgery
3 To whom correspondence should be addressed. E-mail: tguvenal{at}ttnet.net.tr
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