Human Reproduction, Vol. 16, No. 9, 1845-1848,
September 2001
© 2001 European Society of Human Reproduction and Embryology
Spontaneous regression over time of the germinal epithelium in a Y chromosome-microdeleted patient: Case report
1 Division of Endocrinology and Master in Andrological Sciences, New Methodologies in Human Reproductive Medicine, Department of Internal Medicine and 2 Department of Human Anatomy University of Catania, Catania, Italy
Azoospermia factor (AZF) region microdeletions, which account for about 10–15% of patients with oligoazoospermia, seem to lack a close genotype–testicular phenotype correlation. Although many genetic and non-genetic factors may contribute to this outcome, it was thought that a spontaneous regression of testicular germ cells might also play a relevant role. The opportunity for carrying out two different testicular biopsies one year apart in an AZFc-microdeleted patient enabled corroboration of this possibility. Indeed, the first biopsy showed a spermatocyte maturation arrest with mean Johnsen scores of 4 and 3.9 in the right and left testes respectively. One year later, the right testicular biopsy showed a picture of Sertoli cell-only syndrome in 90% of the tubules examined, and of spermatogonial maturation arrest in the remaining tubules, with a mean Johnsen score of 2.1. The almost complete absence of germinal cells was confirmed by four left testicular sperm aspirations (TESA), conducted at the same time as the biopsy during an intracytoplasmic sperm injection cycle, which showed the almost exclusive presence of Sertoli cells (85% of the whole cell population). No spermatozoa could be retrieved by TESA or testicular biopsy. To our knowledge, this is the first case of a spontaneous regression of the germinal cell epithelium over time in a patient with a Yq microdeletion without the apparent intervention of any cause known to affect the germinal epithelium.
Key words: azoospermia factor/germinal epithelium/oligoazoospermia/spermatogenesis/Y chromosome microdeletion
3 To whom correspondence should be addressed at: Istituto di Medicina Interna e Specialità Internistiche, Cattedra di Endocrinologia, Ospedale Garibaldi, Piazza S. Maria di Gesù, 951213 Catania, Italy. E-mail: acaloger{at}unict.it
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