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Human Reproduction, Vol. 16, No. 9, 1909-1911, September 2001
© 2001 European Society of Human Reproduction and Embryology

Birth of a healthy girl after ICSI with ejaculated spermatozoa from a man with non-mosaic Klinefelter's syndrome: Case report

D. Crüger1,3, B. Toft2, I. Agerholm2, J. Fedder2, F. Hald2 and G. Bruun-Petersen1

1 Department of Clinical Genetics, Vejle Hospital, DK-7100 Vejle and 2 The Fertility Clinic, Braedstrup Hospital, DK-8740 Brædstrup, Denmark

Klinefelter's syndrome is a major contributor to male infertility. Recent reports of births after ICSI with especially testicular spermatozoa from infertile men with this syndrome are promising. The birth of a healthy girl after ICSI treatment with ejaculated spermatozoa from a man with non-mosaic Klinefelter's syndrome is reported. The non-mosaic karyotype was confirmed by chromosome analysis of both peripheral blood leukocytes and fibroblasts from a skin biopsy. In conclusion, in a very few cases, men with apparently non-mosaic Klinefelter's syndrome have ejaculated spermatozoa that can result in a birth of a healthy child following ICSI.

Key words: chromosome analysis/fertility/ICSI/Klinefelter's syndrome/non-mosaicism

3 To whom correspondence should be addressed. E-mail: dgc{at}vs.vejleamt.dk


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