Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (21)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Lundorff, P.
Right arrow Articles by diZerega, G. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lundorff, P.
Right arrow Articles by diZerega, G. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 16, No. 9, 1982-1988, September 2001
© 2001 European Society of Human Reproduction and Embryology

Reduction of post-surgical adhesions with ferric hyaluronate gel: a European study

Per Lundorff1,, Hans van Geldorp2,, Sven Erik Tronstad3,, Othon Lalos4,, Bertil Larsson4,, Douglas B. Johns5,7, and Gere S. diZerega6,

Departments of Obstetrics and Gynecology, 1 Viborg Sygehus, Denmark, 2 University Hospital Rotterdam, The Netherlands, 3 Skovde Hospital, Sweden and 4 Danderyd Hospital, Sweden, 5 Ethicon Inc., Somerville, New Jersey 08876 and 6 School of Medicine, University of Southern California, Los Angeles, USA

BACKGROUND: The objective of this study was to assess the safety and efficacy of a 0.5% ferric hyaluronate gel, in reducing adhesions in patients undergoing peritoneal cavity surgery by laparotomy, with a planned `second-look' laparoscopy. METHODS: The study was a randomized (by computer-generated schedule), third party blinded, placebo-controlled, parallel-group design conducted at five centres in Europe. Females aged 18–46 years received 300 ml ferric hyaluronate (n = 38) or lactated Ringer's (n = 39) as an intraperitoneal instillate at the completion of surgery. At second-look 6–12 weeks later, the presence of adhesions was evaluated at 24 abdominal sites. RESULTS: Patients treated with ferric hyaluronate had significantly fewer adhesions compared with controls. When adhesions formed, they were significantly less extensive and less severe in the treated group. The American Fertility Society score for adnexal adhesions was reduced by 69% in the treatment group compared with controls. The safety profile of ferric hyaluronate-treated patients was comparable with those treated with lactated Ringer's solution. CONCLUSIONS: In conclusion, ferric hyaluronate was safe and highly efficacious in reducing the number, severity and extent of adhesions throughout the abdomen following peritoneal cavity surgery.

Key words: adhesion prevention/clinical/ferric hyaluronate/peritoneal cavity surgery/lactated Ringer's solution

7 To whom correspondence should be addressed. E-mail: djohns{at}ethus.jnj.com


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. Zhou, R. S. Liwski, C. Elson, and T. D.G. Lee
Reduction in postsurgical adhesion formation after cardiac surgery in a rabbit model using N,O-carboxymethyl chitosan to block cell adherence.
J. Thorac. Cardiovasc. Surg., April 1, 2008; 135(4): 777 - 783.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
C. Nappi, A. Di Spiezio Sardo, E. Greco, M. Guida, S. Bettocchi, and G. Bifulco
Prevention of adhesions in gynaecological endoscopy
Hum. Reprod. Update, July 1, 2007; 13(4): 379 - 394.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P. Lundorff, J. Donnez, M. Korell, A.J.M. Audebert, K. Block, and G.S. diZerega
Clinical evaluation of a viscoelastic gel for reduction of adhesions following gynaecological surgery by laparoscopy in Europe
Hum. Reprod., February 1, 2005; 20(2): 514 - 520.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.