Human Reproduction, Vol. 17, No. 1, 201-206,
January 2002
© 2002 European Society of Human Reproduction and Embryology
Quantification of Doppler signal in polycystic ovary syndrome using three-dimensional power Doppler ultrasonography: a possible new marker for diagnosis
1 Department of Obstetrics and Gynaecology, National Cheng Kung University Hospital and 2 Institute of Behavioural Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
BACKGROUND: Differences in the ovarian stromal blood flow of women embarking on an IVF treatment, as assessed on day 2 or 3 of the menstrual cycle, using three-dimensional (3D) power Doppler ultrasonography to quantify the blood flow and vascularization, were compared. METHODS: The women were divided into two groups: group 1, 54 women with regular, ovulatory menstrual cycles and normal ovaries on ultrasound scan; and group 2, 25 women with polycystic ovary syndrome (PCOS). RESULTS: The quantification of Doppler signal in the ovarian stroma appeared to be greater in the PCOS group compared with the normal group. The mean of ovarian volume was significantly higher (P < 0.05) in women with PCOS compared with the normal ovaries. The vascularization flow index (VFI), flow index (FI), and vascularization index (VI), were significantly higher (P < 0.05) in the women with PCOS compared with the women with normal ovaries. CONCLUSIONS: This observation may help to explain the excessive response often seen during gonadotrophin administration in women with PCOS. We believe that a quantification study of the vascular flow, including the VI, FI, and VFI of the entire ovarian stroma using 3D power Doppler, is more accurate than the previously reported quantification analysis using 2D imaging, and may be a new parameter to assist in the ultrasound diagnosis of PCOS.
Key words: ovarian stroma/PCOS/power Doppler/stromal blood flow/three-dimensional ultrasound
3 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, National Cheng Kung University Hospital, 138 Victory Road, Tainan 70428, Taiwan. E-mail: fchang{at}mail.ncku.edu.tw
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. M. Hope, K. Long, M. Kudla, A. Arslan, T. Tsymbal, I. Strok, and I. E. Timor-Tritsch Three-Dimensional Power Doppler Angiography of Cyclic Ovarian Blood Flow J. Ultrasound Med., August 1, 2009; 28(8): 1043 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Delgado-Rosas, M. Gaytan, C. Morales, R. Gomez, and F. Gaytan Superficial ovarian cortex vascularization is inversely related to the follicle reserve in normal cycling ovaries and is increased in polycystic ovary syndrome Hum. Reprod., May 1, 2009; 24(5): 1142 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhou, N. Ohno, N. Terada, S. Saitoh, I. Naito, and S. Ohno Permselectivity of blood follicle barriers in mouse ovaries of the mifepristone-induced polycystic ovary model revealed by in vivo cryotechnique Reproduction, November 1, 2008; 136(5): 599 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Lam, I. R. Johnson, and N. J. Raine-Fenning Three-dimensional ultrasound features of the polycystic ovary and the effect of different phenotypic expressions on these parameters Hum. Reprod., December 1, 2007; 22(12): 3116 - 3123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.D. Taylor, H. Wilson, S.G. Hillier, S.J. Wiegand, and H.M. Fraser Effects of inhibition of vascular endothelial growth factor at time of selection on follicular angiogenesis, expansion, development and atresia in the marmoset Mol. Hum. Reprod., October 1, 2007; 13(10): 729 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Jokubkiene, P. Sladkevicius, L. Rovas, and L. Valentin Assessment of changes in volume and vascularity of the ovaries during the normal menstrual cycle using three-dimensional power Doppler ultrasound Hum. Reprod., October 1, 2006; 21(10): 2661 - 2668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. T. Merce, S. Bau, M. J. Barco, J. Troyano, R. Gay, F. Sotos, and A. Villa Assessment of the ovarian volume, number and volume of follicles and ovarian vascularity by three-dimensional ultrasonography and power Doppler angiography on the HCG day to predict the outcome in IVF/ICSI cycles Hum. Reprod., May 1, 2006; 21(5): 1218 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Y. Ng, C. C. W. Chan, W. S. B. Yeung, and P. C. Ho Comparison of ovarian stromal blood flow between fertile women with normal ovaries and infertile women with polycystic ovary syndrome Hum. Reprod., July 1, 2005; 20(7): 1881 - 1886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Fraser, H. Wilson, J. S. Rudge, and S. J. Wiegand Single Injections of Vascular Endothelial Growth Factor Trap Block Ovulation in the Macaque and Produce a Prolonged, Dose-Related Suppression of Ovarian Function J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 1114 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hata, E. Inubashiri, K. Kanenishi, M. Akiyama, H. Tanaka, and T. Yanagihara Three-Dimensional Power Doppler Angiographic Features of Placental Chorioangioma J. Ultrasound Med., November 1, 2004; 23(11): 1517 - 1520. [Full Text] [PDF]
|
|
|
|
|
|
E. H. Y. Ng, C. C. W. Chan, W. S. B. Yeung, and P. C. Ho Effect of age on ovarian stromal flow measured by three-dimensional ultrasound with power Doppler in Chinese women with proven fertility Hum. Reprod., September 1, 2004; 19(9): 2132 - 2137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Lee, K. D. Kalache, T. Chaiworapongsa, J. Londono, M. C. Treadwell, A. Johnson, and R. Romero Three-dimensional Power Doppler Ultrasonography During Pregnancy J. Ultrasound Med., January 1, 2003; 22(1): 91 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.J. Raine-Fenning Quantification of Doppler signal in polycystic ovarian syndrome using 3D power Doppler ultrasonography Hum. Reprod., September 1, 2002; 17(9): 2483 - 2484. [Full Text] [PDF]
|
|