Human Reproduction, Vol. 17, No. 1, 69-75,
January 2002
© 2002 European Society of Human Reproduction and Embryology
IL-1, IL-6 and TNF-
concentrations in the peritoneal fluid of women with pelvic adhesions
1 The Jessop Wing, Central Sheffield University Hospitals, Tree Root Walk, Sheffield, S10 2PS, 2 Division of Biomedical Sciences/BMRC, Sheffield Hallam University, City Campus, Sheffield S1 1WB and 3 Sheffield Virology Service, Sheffield Teaching Hospital Trust, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
BACKGROUND: Pelvic adhesions are a significant cause of morbidity and are associated with infertility and pain. The three pro-inflammatory cytokines interleukin (IL)-1, IL-6 and tumour necrosis factor (TNF)-
are involved in adhesion formation/reformation. METHODS: The concentration of these three cytokines was examined in the peritoneal fluid of women undergoing laparoscopy, in order to examine the factors affecting their concentrations, with specific reference to the presence or absence of adhesions. RESULTS: We found that the concentration of TNF- in the peritoneal fluid was significantly correlated to the menstrual cycle day (P < 0.01), with increasing concentration as the menstrual cycle progressed from the follicular to the luteal phase. In contrast, IL-1 and IL-6 levels did not show any variation throughout the menstrual cycle. Increased TNF- was found in patients with pelvic adhesions compared with those with normal pelvis; the concentration of TNF- was highest in mild compared with severe adhesions. In contrast, IL-1 concentration was higher in the presence of severe adhesions. IL-6 levels were significantly correlated with the grade of endometriosis (P < 0.05), but there were no significant correlations of either TNF- or IL-1 concentrations with the various grades of endometriosis. CONCLUSION: The exact role of TNF- and IL-1 in adhesion formation is still unknown, but the results from this study suggest that their concentration in the peritoneal fluid is associated with the degree of adhesions present.
Key words:
endometriosis/interleukin/menstrual cycle/peritoneal fluid/TNF-
4 To whom correspondence should be addressed at: The Jessop Wing, Royal Hallamshire Hospital, Tree Root Walk, Sheffield S10 2SF, UK. E-mail: yingcheong{at}hotmail.com
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